Synthesis and anticancer activity of 2,3,4-trimethoxyacetophenoxime ester containing benzothiazole moiety

被引：22

作者：

Song, BA ^{[1
]}

Liu, XH ^{[1
]}

Yang, S ^{[1
]}

Hu, DY ^{[1
]}

Jin, LH ^{[1
]}

Zhang, H ^{[1
]}

机构：

[1] Guizhou Univ, Ctr Res & Dev Fine Chem, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2005年 / 23卷 / 09期

关键词：

oxime ester; synthesis; anticancer activity;

D O I：

10.1002/cjoc.200591236

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 2,3,4-trimethoxyacetophenoxime esters containing benzothiazole moiety were synthesized by the reaction of oxime with acyl chloride in alkaline medium. Their structures were established by elemental analysis, IR, and H-1 NMR spectra. The bioassay tests showed that these tide compounds exhibit moderate anticancer activity in vitro by MTT method and compounds 6c and 6d could inhibit ERK phosphorylation in NIH 3T3 cell induced by PDGF.

引用

页码：1236 / 1240

页数：5

共 22 条

[11]

Shi YN, 1995, CHEM J CHINESE U, V16, P1710

[12] NEW COLORIMETRIC CYTOTOXICITY ASSAY FOR ANTICANCER-DRUG SCREENING [J].

SKEHAN, P ;

STORENG, R ;

SCUDIERO, D ;

MONKS, A ;

MCMAHON, J ;

VISTICA, D ;

WARREN, JT ;

BOKESCH, H ;

KENNEY, S ;

BOYD, MR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (13) :1107-1112

[13]

Song BA, 2001, CHINESE J ORG CHEM, V21, P524

[14]

Vonhoff S, 1999, HELV CHIM ACTA, V82, P963, DOI 10.1002/(SICI)1522-2675(19990707)82:7<963::AID-HLCA963>3.0.CO

[15]

2-V

[16] Design and implementation of an efficient synthetic approach to pyranosylated indolocarbazoles: Total synthesis of (+)-RK286c, (+)-MLR-52, (+)-staurosporine, and (-)-TAN-1030a [J].

Wood, JL ;

Stoltz, BM ;

Goodman, SN ;

Onwneme, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (41) :9652-9661

[17]

Yang S, 2002, CHINESE J ORG CHEM, V22, P345

[18]

YANG S, 2002, CHEMISTRY, V3, P198

[19]

[杨松 Yang Song], 2002, [应用化学, Chinese Journal of Applied Chemistry], V19, P259

[20]

[杨松 Yang Song], 2002, [农药学学报, Chinese journal of pesticide science], V4, P23

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