A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

被引：30

作者：

Baglai, Iaroslav ^{[1
]}

Leeman, Michel ^{[2
]}

Kellogg, Richard M. ^{[2
]}

Noorduin, Willem L. ^{[1
]}

机构：

[1] AMOLF, Sci Pk 104, NL-1098 XG Amsterdam, Netherlands

[2] Syncom BV, Kadijk 3, NL-9747 AT Groningen, Netherlands

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 01期

关键词：

Building blockes - Enantiopure - Levetiracetam - Rational design - Ripening process;

D O I：

10.1039/c8ob02660b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple route to enantiomerically pure (S)-2-aminobutyramide - the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

引用

页码：35 / 38

页数：4

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