MUC1 Aptamer-Based Near-Infrared Fluorescence Probes for Tumor Imaging

被引：28

作者：

Chen, Haiyan ^{[1
]}

Zhao, Juan ^{[1
]}

Zhang, Min ^{[1
]}

Yang, Haibo ^{[2
]}

Ma, Yuxiang ^{[1
]}

Gu, Yueqing ^{[1
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Sch Life Sci & Technol, Dept Biomed Engn, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China

来源：

MOLECULAR IMAGING AND BIOLOGY | 2015年 / 17卷 / 01期

关键词：

MUC1; aptamer; Tumor targeting; PEG; Near-infrared fluorescence; Tumor imaging; IN-VIVO; CANCER; NANOPARTICLE; NUCLEOLIN; MUCINS; DYES;

D O I：

10.1007/s11307-014-0763-y

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: DNA aptamer (APT) is able to bind to Mucin 1 (MUC1) specifically. The possibility of APT acting as a moiety to construct tumor-targeting probes was investigated. Procedures: A near-infrared (NIR) fluorescent dye (MPA) and polyethylene glycol (PEG) were conjugated to APT to form APT-MPA and APT-PEG-MPA. The successful synthesis of the two probes was characterized via thin layer chromatography (TLC) and optical spectra. The tumor-targeting efficacy of the probes was evaluated in detail at cell level and animal level, respectively. Results: The results indicated that MPA and PEG were successfully coupled with APT. APT-based probes were mediated by Mucin 1 into tumor cells, and PEG-modified probe exhibited higher cell affinity. Conclusions: The aptamer-based NIR fluorescent probes are promising candidates for tumor imaging and diagnosis.

引用

页码：38 / 48

页数：11

共 50 条

[31] Hemicyanine-Based Near-Infrared Activatable Probes for Imaging and Diagnosis of Diseases
Zeng, Ziling
Liew, Si Si
Wei, Xin
Pu, Kanyi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (51) : 26454 - 26475
[32] Advances in the Development of Multimodal Imaging Agents for Nuclear/Near-infrared Fluorescence Imaging
Ghosh, S. C.
Azhdarinia, A.
CURRENT MEDICINAL CHEMISTRY, 2015, 22 (29) : 3390 - 3404
[33] Impact of Substituents in Tumor Uptake and Fluorescence Imaging Ability of Near-Infrared Cyanine-like Dyes
Patel, Nayan J.
Manivannan, Ethirajan
Joshi, Penny
Ohulchanskyy, Tymish J.
Nani, Roger R.
Schnermann, Martin J.
Pandey, Ravindra K.
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2015, 91 (05) : 1219 - 1230
[34] High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor
Xu, Kehua
Wang, Feng
Pan, Xiaohong
Liu, Renpu
Ma, Jing
Kong, Fanpeng
Tang, Bo
CHEMICAL COMMUNICATIONS, 2013, 49 (25) : 2554 - 2556
[35] Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue
van der Vorst, Joost R.
Vahrmeijer, Alexander L.
Hutteman, Merlijn
Bosse, Tjalling
Smit, Vincent T. H. B. M.
De Velde, Cornelis J. H. van
Frangioni, John V.
Bonsing, Bert A.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY, 2012, 4 (07): : 180 - 184
[36] Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature
Cai, Weibo
Chen, Kai
Li, Zi-Bo
Gambhir, Sanjiv S.
Chen, Xiaoyuan
JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (11) : 1862 - 1870
[37] Excitation-Selectable Nanoprobe for Tumor Fluorescence Imaging and Near-Infrared Thermal Therapy
Wei, Yanchun
Chen, Qun
Wu, Baoyan
Xing, Da
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2016, 12 (01) : 91 - 102
[38] Folate-modified gold nanoclusters as near-infrared fluorescent probes for tumor imaging and therapy
Chen, Haiyan
Li, Shulan
Li, Bowen
Ren, Xueyan
Li, Shengnan
Mahounga, Didel M.
Cui, Sisi
Gu, Yueqing
Achilefu, Samuel
NANOSCALE, 2012, 4 (19) : 6050 - 6064
[39] Near-infrared fluorescence imaging of thoracic duct in minimally invasive esophagectomy
Yang, Feng
Gao, Jian
Cheng, Sida
Li, Hao
He, Kunshan
Zhou, Jian
Chen, Kezhong
Wang, Zhenfan
Yang, Fan
Zhang, Zeyu
Li, Jianfeng
Zhou, Zuli
Chi, Chongwei
Li, Yun
Wang, Jun
DISEASES OF THE ESOPHAGUS, 2023, 36 (02)
[40] Application of Near-Infrared Fluorescence Imaging in Thrombosis Detection
Zhang, Wen
Li, Mengmei
Wang, Xin
Li, Ping
Tang, Bo
ANALYSIS & SENSING, 2023, 3 (01):

← 1 2 3 4 5 →