Advanced Parkinson's Disease Treatment Simplification and Long-Term Outcomes with Levodopa Carbidopa Intestinal Gel: COSMOS Romanian Subanalysis

被引：8
作者：
Simu, Mihaela Adriana [1 ]
Jianu, Dragos Catalin [1 ]
Dulamea, Adriana Octaviana [2 ]
Constantin, Viorelia Adelina [3 ]
Popescu, Diana [4 ]
Parra, Juan Carlos [5 ]
Szasz, Jozsef Attila [6 ]
机构：
[1] Victor Babes Univ Med & Pharm, Dept Neurol, Timisoara 300041, Romania
[2] Carol Davila Univ Med & Pharm, Neurol Clin, Fundeni Clin Inst, Bucharest 020021, Romania
[3] Emergency Clin Cty Hosp Targu Mures, Dept Neurol, Targu Mures 540136, Romania
[4] AbbVie Soc Ltd Responsibil, Bucharest 020276, Romania
[5] AbbVie Inc, N Chicago, IL 60085 USA
[6] George Emil Palade Univ Med Pharm Sci & Technol, Dept Neurol, Targu Mures 540139, Romania
来源：
BRAIN SCIENCES | 2021年 / 11卷 / 12期
关键词：
Parkinson's disease; levodopa carbidopa intestinal gel; LCIG; monotherapy; device aided therapies; DAT; COSMOS; routine clinical practice; NEUROLOGY CLINICS; NONMOTOR SYMPTOMS; SLEEP DISORDERS; DOUBLE-BLIND; LARGE COHORT; INFUSION; QUESTIONNAIRE; PHARMACOKINETICS; COMPLICATIONS; EXPERIENCE;
D O I：
10.3390/brainsci11121566
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The aim of the COmedication Study assessing Mono- and cOmbination therapy with levodopa-carbidopa inteStinal gel (COSMOS) was to assess the use of levodopa/carbidopa intestinal gel (LCIG) as monotherapy in patients with advanced Parkinson's disease (APD) in routine clinical practice. COSMOS was an international observational study with one cross-sectional visit and retrospective data collection. In Romania, 95 adult patients with APD on LCIG treatment for at least 12 months were enrolled and stratified according to their LCIG therapy after 12 months: monotherapy (without any add-on PD medication), monotherapy with night PD medication and LCIG + add-on medication. Compared to the moment of LCIG initiation, the percentage of patients on monotherapy increased at three months after LCIG initiation and remained constant up to 12 months, when 30.5% of the patients were on LCIG monotherapy and 11.6% were on monotherapy with night medication. "Off" time and "On" time with dyskinesia decreased from LCIG initiation to patient visit in all groups. LCIG monotherapy with or without night medication may provide a simplified treatment option for selected APD patients, with long-term efficacy similar to that of LCIG plus add-on medication.
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页数：17
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