Ventilator-associated pneumonia in neonates and children: a systematic analysis of diagnostic methods and prevention

被引：50

作者：

Iosifidis, Elias ^{[1
]}

Pitsava, Georgia ^{[1
]}

Roilides, Emmanuel ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Hlth Sci, Hippokrat Gen Hosp, Infect Dis Unit,Dept Pediat 3,Med Fac, Thessaloniki, Greece

来源：

FUTURE MICROBIOLOGY | 2018年 / 13卷 / 12期

关键词：

critical illness; diagnosis; pediatrics; pneumonia; ventilator-associated; PEDIATRIC INTENSIVE-CARE; CRITICALLY-ILL CHILDREN; PULMONARY INFECTION SCORE; FOR-DISEASE-CONTROL; NOSOCOMIAL INFECTIONS; UNIT PATIENTS; 0.12-PERCENT CHLORHEXIDINE; DEVELOPING-COUNTRIES; CONTROLLED-TRIAL; RISK-FACTORS;

D O I：

10.2217/fmb-2018-0108

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: While ventilator-associated pneumonia (VAP) remains frequent in Pediatric ICU, there is no gold standard for diagnosis. Methodology: We conducted a systematic PUBMED analysis (January 1990-January 2017) searching original, full-length studies addressing only pediatric patients; for VAP diagnosis, only those comparing different diagnostic methods and for VAP prevention those implementing preventive measures. Results: Among 367 articles, 17 and 16 were analyzed for diagnosis and prevention, respectively. For diagnosis, 13 studies used CDC criteria; whereas, 14 assessed algorithms: clinical pulmonary index score, ventilator-associated events and biomarkers. Among five randomized trials assessing preventive strategies one found a role of probiotics. Ventilator-care bundles reduced VAP rates. Conclusion: Absence of diagnostic gold standard impedes comparison of current approaches and preventive strategies.

引用

页码：1431 / 1446

页数：16

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