No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease

被引：8

作者：

Turunen, Mari

Vepsalainen, Saila

Makinen, Petra

Helisalrni, Seppo

Haapasalo, Annakaisa

Soininen, Hilkka

Hiltunen, Mikko ^{[1
]}

机构：

[1] Univ Hosp, Dept Neurol, Clin Res Ctr Mediteknia, Kuopio 70211, Finland

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 03期

基金：

芬兰科学院;

关键词：

Alzheimer's disease; HTRA1; Risk gene; SNP;

D O I：

10.1016/j.neurobiolaging.2009.08.010

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

High temperature requirement 1 (HTRA1) gene is a plausible risk factor in Alzheimer's disease (AD) as it encodes a protease known to degrade amyloid-beta peptide. Here we have studied whether single nucleotide polymorphisms (SNPs) in the HTRA1 gene or its nearby regions associated with AD in a large clinic-based case control cohort originating from Finland. We did not observe significant association of the HTRA1 SNPs with AD among the whole case control cohort or age-at-onset risk effect among AD patients. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：547.e7 / 547.e9

页数：3

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