Synthesis of Multisubstituted Allylic Alcohols via a Nickel-Catalyzed Cross-Electrophile Ring-Opening Reaction

被引：8
|
作者：
Hu, Weitao [1 ]
Lin, Zhiyang [1 ]
Wang, Chuan [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[2] Chinese Acad Sci, Ctr Excellence Mol Synth, Hefei 230026, Anhui, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 31期
基金：
中国国家自然科学基金;
关键词：
STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; COUPLING REACTIONS; GROWTH-INHIBITION; VINYL EPOXIDES; HALIDES; TAMOXIFEN; DERIVATIVES; ALDEHYDES; VIOXX(R);
D O I：
10.1021/acs.orglett.2c02199
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report a nickel-catalyzed cross-electrophile ring-opening reaction of vinyl epoxides wherein aryl iodides, alkyl iodides, and benzyl chlorides can all serve as the electrophilic coupling partners, providing a new approach to preparing multisubstituted allylic alcohols. This new method features broad substrate scope (76 examples), good step-economy, and high L/B-and E/Z selectivity as well as mild reaction conditions.
引用
收藏
页码：5751 / 5755
页数：5
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