Synthesis of new ent-labdane diterpene derivatives from andrographolide and evaluation on cytotoxic activities

被引：29

作者：

Luo, Yan ^{[1
]}

Wang, Ke ^{[2
,3
]}

Zhang, Meng-han ^{[2
,3
]}

Zhang, Da-yong ^{[2
,3
]}

Wu, Yang-chang ^{[4
]}

Wu, Xiao-ming ^{[2
,3
]}

Hua, Wei-yi ^{[2
,3
]}

机构：

[1] Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Peoples R China

[2] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Jiangsu, Peoples R China

[3] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

[4] China Med Univ, Coll Pharm, Grad Inst Pharmaceut Chem, Taichung 40402, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Andrographolide; ent-Labdane diterpene; SAR; Cytotoxic activity; ANALOGS; AGENTS; PANICULATA;

D O I：

10.1016/j.bmcl.2015.03.086

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

There are many reports for andrographolide modification regarding antitumor effects. Transformation of the five-membered lactone ring to furan aromatic ring still results in compounds with good cytotoxicity. To determine further the importance of the five-membered lactone ring and to obtain better lead compounds, we transformed the five-membered lactone ring in andrographolide. New types of ent-labdane diterpene derivatives were made, whose cytotoxic activities were measured in vitro. Preliminary SAR was summarized and two compounds, 7 and 26, with good cytotoxic activity were obtained, which have the potential to be developed into new antitumor drugs. (C) 2015 Published by Elsevier Ltd.

引用

页码：2421 / 2424

页数：4

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