New perspectives regarding β2-adrenoceptor ligands in the treatment of asthma

被引：72
作者：
Walker, J. K. L. [2 ]
Penn, R. B. [3 ]
Hanania, N. A. [4 ]
Dickey, B. F. [5 ]
Bond, R. A. [1 ]
机构：
[1] Univ Houston, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77004 USA
[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
[3] Univ Maryland, Dept Med, Baltimore, MD 21201 USA
[4] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[5] Univ Texas MD Anderson Canc Ctr, Dept Pulm Med, Houston, TX 77030 USA
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2011年 / 163卷 / 01期
关键词：
asthma; beta(2)-adrenoceptor; agonist; inverse agonist; constitutive activity; biased agonism; efficacy; BETA-ADRENERGIC-RECEPTOR; AIRWAY SMOOTH-MUSCLE; PROTEIN-COUPLED RECEPTORS; THYMIC STROMAL LYMPHOPOIETIN; CONSTITUTIVE ACTIVITY; BRONCHODILATOR SUBSENSITIVITY; MELANOCORTIN-4; RECEPTOR; MILD ASTHMA; ARRESTIN; AGONISTS;
D O I：
10.1111/j.1476-5381.2010.01178.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
LINKED ARTICLES This article is part of a themed issue on Respiratory Pharmacology. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2011.163.issue-1.
引用
收藏
页码：18 / 28
页数：11
相关论文
共 96 条
  • [1] ARIENS EJ, 1954, ARCH INT PHARMACOD T, V99, P32
  • [2] SOME QUANTITATIVE USES OF DRUG ANTAGONISTS
    ARUNLAKSHANA, O
    SCHILD, HO
    [J]. BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1959, 14 (01): : 48 - 58
  • [3] ATTRAMADAL H, 1992, J BIOL CHEM, V267, P17882
  • [4] RETRACTED: β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi (Retracted Article)
    Baillie, GS
    Sood, A
    McPhee, I
    Gall, I
    Perry, SJ
    Lefkowitz, RJ
    Houslay, MD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) : 940 - 945
  • [5] Meta-analysis: Effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events
    Bateman, Eric
    Nelson, Harold
    Bousquet, Jean
    Kral, Kenneth
    Sutton, Laura
    Ortega, Hector
    Yancey, Steven
    [J]. ANNALS OF INTERNAL MEDICINE, 2008, 149 (01) : 33 - +
  • [6] BENOVIC JL, 1985, J BIOL CHEM, V260, P7094
  • [7] Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
    Berg, KA
    Maayani, S
    Goldfarb, J
    Scaramellini, C
    Leff, P
    Clarke, WP
    [J]. MOLECULAR PHARMACOLOGY, 1998, 54 (01) : 94 - 104
  • [8] Billington CK, 2003, RESP RES, V4
  • [9] μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
    Bohn, LM
    Gainetdinov, RR
    Lin, FT
    Lefkowitz, RJ
    Caron, MG
    [J]. NATURE, 2000, 408 (6813) : 720 - 723
  • [10] Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery
    Bond, RA
    IJzerman, AP
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2006, 27 (02) : 92 - 96
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