Genomics of chronic allograft injury

被引：17

作者：

Akalin, Enver ^{[1
,2
]}

O'Connell, Philip J. ^{[3
]}

机构：

[1] Montefiore Med Ctr, Albert Einstein Coll Med, Abdominal Transplant Program, Bronx, NY 10467 USA

[2] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Clin Med, Kidney Transplant Program,Renal Div, Bronx, NY 10467 USA

[3] Univ Sydney, Westmead Hosp, Ctr Transplant & Renal Res, Westmead Millennium Inst, Westmead, NSW 2145, Australia

来源：

KIDNEY INTERNATIONAL | 2010年 / 78卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Affymetrix; chronic rejection; GeneChip; kidney transplantation; microarray; TO-MESENCHYMAL TRANSITION; HUMAN KIDNEY-TRANSPLANTS; GENE-EXPRESSION; OXIDATIVE STRESS; DONOR KIDNEYS; REJECTION; MICROARRAY; BIOPSIES; ANTIBODY; TRANSCRIPTOME;

D O I：

10.1038/ki.2010.420

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic allograft injury (CAI) is common after kidney transplantation in which immunological (e.g., acute and chronic cellular and antibody-mediated rejection) and nonimmunological factors (e.g., donor-related factors, ischemia-reperfusion injury, polyoma virus, hypertension, and calcineurin inhibitor nephrotoxicity) have a role. Despite the new Banff pathological classification, histopathological diagnosis is still far from being the 'gold standard' to understand the exact mechanisms in the development of CAI, which may lead to appropriate treatment. Microarray is a powerful technology that detects thousands of genes simultaneously and might be an important tool in elucidating patterns for mechanism, diagnosis, prognosis, and treatment of complex, multifactorial diseases, such as CAI. In this review, we discuss the studies that applied microarray technology in kidney transplant patients with CAI.

引用

页码：S33 / S37

页数：5

共 36 条

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