Recurrence-free survival more than 10 years after liver resection for hepatocellular carcinoma

被引：74

作者：

Eguchi, S. ^{[1
]}

Kanematsu, T. ^{[1
]}

Arii, S. ^{[2
]}

Omata, M. ^{[3
]}

Kudo, M. ^{[4
]}

Sakamoto, M. ^{[5
]}

Takayasu, K. ^{[6
]}

Makuuchi, M. ^{[7
]}

Matsuyama, Y. ^{[8
]}

Monden, M. ^{[9
]}

机构：

[1] Nagasaki Univ, Dept Surg, Grad Sch Biomed Sci, Nagasaki 8528501, Japan

[2] Tokyo Med & Dent Univ, Grad Sch Med, Dept Hepatobiliary Pancreat Surg, Yamanashi, Japan

[3] Yamanashi Prefectural Cent Hosp, Dept Gastroenterol, Yamanashi, Japan

[4] Kinki Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Tokyo, Japan

[5] Keio Univ, Dept Pathol, Tokyo, Japan

[6] Natl Canc Ctr, Dept Diagnost Radiol, Tokyo, Japan

[7] Japanese Red Cross Med Ctr, Dept Surg, Tokyo, Japan

[8] Univ Tokyo, Dept Biostat, Sch Hlth Sci & Nursing, Tokyo, Japan

[9] Osaka Univ, Grad Sch Med, Dept Surg, Osaka, Japan

来源：

BRITISH JOURNAL OF SURGERY | 2011年 / 98卷 / 04期

关键词：

LONG-TERM SURVIVORS; CLINICOPATHOLOGICAL FEATURES; HEPATECTOMY; DISEASE;

D O I：

10.1002/bjs.7393

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: High recurrence rates after liver resection with curative intent for hepatocellular carcinoma (HCC) remain a problem. The characterization of long-term survivors without recurrence after liver resection may help improve the therapeutic strategy for HCC. Methods: A nationwide Japanese database was used to analyse 20 811 patients with HCC who underwent liver resection with curative intent. Results: The 10-year recurrence-free survival rate after liver resection for HCC with curative intent was 22.4 per cent. Some 281 patients were recurrence-free after more than 10 years. The HCCs measured less than 5 cm in 83.2 per cent, a single lesion was present in 91.7 per cent, and a simple nodular macroscopic appearance was found in 73.3 per cent of these patients; histologically, most HCCs showed no vascular invasion or intrahepatic metastases. Multivariable analysis revealed tumour differentiation as the strongest predictor of death from recurrent HCC within 5 years. Conclusion: Long-term recurrence-free survival is possible after liver resection for HCC, particularly in patients with a single lesion measuring less than 5 cm with a simple nodular appearance and low tumour marker levels.

引用

页码：552 / 557

页数：6

共 17 条

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