Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma

被引：19
作者：
Hung, CH
Li, CY
Lai, YS
Hsu, PC
Hua, YM
Yang, KD
机构：
[1] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pediat, Taipei 114, Taiwan
[2] Triserv Gen Hosp, Natl Def Med Ctr, Dept Anesthesiol, Taipei 114, Taiwan
[3] Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Taipei 114, Taiwan
[4] Chang Gung Childrens Hosp, Kaohsiung, Taiwan
来源：
PEDIATRIC ALLERGY AND IMMUNOLOGY | 2005年 / 16卷 / 04期
关键词：
thymus and activation-regulated chemokine; macrophage-derived chemokine; peak expiratory flow; ketotifen; montelukast;
D O I：
10.1111/j.1399-3038.2005.00273.x
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
In a randomized study, two oral medications, ketotifen and montelukast, were compared for children with mild persistent asthma. Montelukast revealed faster clinical responses than ketotifen, showing improved exhaled nitric oxide, peak expiratory flow, and asthma scores in 1 wk. After 8-wk of medication, both ketotifen and montelukast revealed improved clinical responses. However, 8 wk of ketotifen, but not montelukast, decreased plasma serum thymus and activation-regulated chemokine (317.854 +/- 207.906 vs. 181.348 +/- 167.109, p < 0.05), macrophage-derived chemokine (355.11 +/- 174.30 vs. 169.19 +/- 62.42, p < 0.05) levels. In conclusion, different oral non-steroidal anti-inflammatory drugs revealed faster or slower treatment responses due to different mechanisms.
引用
收藏
页码：306 / 309
页数：4
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