Magnetic fluid poly(ethylene glycol) with moderate anticancer activity

被引：38

作者：

Zavisova, Vlasta ^{[1
]}

Koneracka, Martina ^{[1
]}

Muckova, Marta ^{[2
]}

Lazova, Jana ^{[2
]}

Jurikova, Alena ^{[1
]}

Lancz, Gabor ^{[1
]}

Tomasovicova, Natalia ^{[1
]}

Timko, Milan ^{[1
]}

Kovac, Jozef ^{[1
]}

Vavra, Ivo ^{[3
]}

Fabian, Martin ^{[4
]}

Feoktystov, Artem V. ^{[5
,6
]}

Garamus, Vasil M. ^{[7
]}

Avdeev, Mikhail V. ^{[5
]}

Kopcansky, Peter ^{[1
]}

机构：

[1] IEP SAS, Kosice 04001, Slovakia

[2] Rds AS, Modra, Slovakia

[3] IEE SAS, Kosice 84104, Slovakia

[4] IGT SAS, Kosice 04001, Slovakia

[5] FLNP JINR, Dubna Moscow Reg 141980, Russia

[6] KNU, UA-03187 Kiev, Ukraine

[7] GKSS Forschungszentrum Geesthacht GmbH, D-21502 Geesthacht, Germany

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2011年 / 323卷 / 10期

关键词：

Magnetic fluid; Poly(ethylene glycol); SANS; In vitro test; ANGLE NEUTRON-SCATTERING; CONTRAST-VARIATION; ADSORPTION; KINETICS; DRUGS;

D O I：

10.1016/j.jmmm.2010.11.060

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Poly(ethylene glycol) (PEG)-containing magnetic fluids - magnetite (Fe(3)O(4)) stabilized by sodium oleate - were prepared. Magnetic measurements confirmed superparamagnetic behaviour at room temperature. The structure of that kind of magnetic fluid was characterized using different techniques, including electron microscopy, photon cross correlation spectroscopy and small-angle neutron scattering, while the adsorption of PEG on magnetic particles was analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. From the in vitro toxicity tests it was found that a magnetic fluid containing PEG (MFPEG) partially inhibited the growth of cancerous B16 cells at the highest tested dose (2.1 mg/ml of Fe(3)O(4) in MFPEG). (C) 2010 Published by Elsevier B.V.

引用

页码：1408 / 1412

页数：5

共 13 条

[1] Contrast variation in small-angle scattering experiments on polydisperse and superparamagnetic systems: basic functions approach [J].