Some pyrazoles derivatives: Potent carbonic anhydrase, -glycosidase, and cholinesterase enzymes inhibitors

被引：68
|
作者：
Turkan, Fikret [1 ]
Cetin, Adnan [2 ]
Taslimi, Parham [3 ]
Gulcin, Ilhami [3 ]
机构：
[1] Igdir Univ, Hlth Serv Vocat Sch, Igdir, Turkey
[2] Mus Alparslan Univ, Dept Sci, Fac Educ, Mus, Turkey
[3] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey
来源：
ARCHIV DER PHARMAZIE | 2018年 / 351卷 / 10期
关键词：
acetylcholinesterase; butyrylcholinesterase; carbonic anhydrase; enzyme inhibition; substituted pyrazol-4-yl-diazene; INCLUDING NATURAL-PRODUCTS; GLUTATHIONE-S-TRANSFERASE; ALPHA-GLUCOSIDASE; 1ST SYNTHESIS; ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; PROFILES; ANTIOXIDANT; BROMOPHENOLS; BENZENESULFONAMIDES;
D O I：
10.1002/ardp.201800200
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of substituteed pyrazol-4-yl-diazene derivatives were found to be effective inhibitors against -glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with K-i values in the range of 33.72 +/- 7.93 to 90.56 +/- 27.52nM for -glycosidase, 1.06 +/- 0.16 to 9.83 +/- 0.74nM for hCA I, 0.68 +/- 0.12 to 7.16 +/- 1.14nM for hCA II, 44.66 +/- 10.06 to 78.34 +/- 17.83nM for AChE, and 50.36 +/- 13.88 to 88.36 +/- 20.03nM for BChE, respectively. Recently, inhibition of these metabolic enzymes has been considered as a promising factor for pharmacologic intervention in a diversity of disturbances, such as diabetes, glaucoma, obesity, epilepsy, cancer, and neurodegenerative diseases.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes inhibitors: The novel N,N′-bis-cyanomethylamine and alkoxymethylamine derivatives
    Taslimi, Parham
    Caglayan, Cuneyt
    Farzaliyev, Vagif
    Nabiyev, Oruj
    Sujayev, Afsun
    Turkan, Fikret
    Kaya, Ruya
    Gulcin, Ilhami
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2018, 32 (04)
  • [2] Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties
    Daryadel, Shahla
    Atmaca, Ufuk
    Taslimi, Parham
    Gulcin, Ilhami
    Celik, Murat
    ARCHIV DER PHARMAZIE, 2018, 351 (11)
  • [3] Schiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitors
    Yigit, Beyhan
    Yigit, Murat
    Taslimi, Parham
    Gok, Yetkin
    Gulcin, Ilhami
    ARCHIV DER PHARMAZIE, 2018, 351 (09)
  • [4] Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors
    Okten, Salih
    Ekiz, Makbule
    Kocyigit, Umit Muhammet
    Tutar, Ahmet
    Celik, Ismail
    Akkurt, Mehmet
    Gokalp, Faik
    Taslimi, Parham
    Gulcin, Ilhami
    JOURNAL OF MOLECULAR STRUCTURE, 2019, 1175 : 906 - 915
  • [5] Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
    Turkan, Fikret
    Cetin, Adnan
    Taslimi, Parham
    Karaman, Muhammet
    Gulcin, Ilhami
    BIOORGANIC CHEMISTRY, 2019, 86 : 420 - 427
  • [6] EFFECTS OF SOME TURKISH PLANT EXTRACTS ON CARBONIC ANHYDRASE AND CHOLINESTERASE ENZYMES
    Uras, Ibrahim Seyda
    Kursat, Murat
    Konuklugil, Belma
    Senturk, Murat
    STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA, 2024, 69 (04):
  • [7] The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and -glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study
    Taslimi, Parham
    Caglayan, Cuneyt
    Gulcin, Ilhami
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2017, 31 (12)
  • [8] Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors
    Burmaoglu, Serdar
    Yilmaz, Ali Osman
    Polat, M. Fatih
    Kaya, Ruya
    Gulcin, Ilhami
    Algul, Oztekin
    BIOORGANIC CHEMISTRY, 2019, 85 : 191 - 197
  • [9] Synthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity
    Burmaoglu, Serdar
    Yilmaz, Ali O.
    Taslimi, Parham
    Algul, Oztekin
    Kilic, Deryanur
    Gulcin, Ilhami
    ARCHIV DER PHARMAZIE, 2018, 351 (02)
  • [10] SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors
    Okten, Salih
    Ekiz, Makbule
    Tutar, Ahmet
    Butun, Burcu
    Kocyigit, Umit Muhammet
    Topcu, Gulacti
    Gulcin, Ilhami
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2019, 53 (02) : 268 - 275
12345