Switching on a signaling pathway with an organoruthenium complex

被引：81

作者：

Williams, DS

Atilla, GE

Bregman, H

Arzoumanian, A

Klein, PS

Meggers, E

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Med, Div Hematol Oncol, Philadelphia, PA 19104 USA

[3] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 13期

关键词：

bioinorganic chemistry; enzymes; medicinal; chemistry; ruthenium; signal transduction;

D O I：

10.1002/anie.200462501

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Like an organic molecule! A chemically inert ruthenium complex acts as a metallopharmaceutic inhibitor of the protein kinase GSK-3 by targeting its ATP-binding site. It is shown to switch on the Wnt signal transduction pathway inside living cells and in Xenopus embryos, which developed a hyperdorsalized phenotype (see picture, top; bottom: control specimen) on administration of the complex. (Figure Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1984 / 1987

页数：4

共 36 条

[1] An organometallic inhibitor for glycogen synthase kinase 3 [J].