Concise Three-Step Strategy for the Synthesis of 2-Benzoxepin-3(1H)-ones

被引：8

作者：

Madhurima, Hazra ^{[1
]}

Krishna, Jonnada ^{[1
]}

Satyanarayana, Gedu ^{[1
]}

机构：

[1] Indian Inst Technol IIT Hyderabad, Yeddumailaram 502205, Telangana, India

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 09期

关键词：

palladium catalysis; Heck coupling; reduction; condensation; benzoxepinones; REGIOSELECTIVE HECK COUPLINGS; HPLC-SPE-NMR; ASYMMETRIC-SYNTHESIS; MICHAEL REACTION; METABOLITES; CYCLIZATION; DIVERSITY; CHEMISTRY; FUNGI;

D O I：

10.1055/s-0034-1379901

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and efficient method was developed for the synthesis of 2-benzoxepin-3(1H)-ones. The synthetic sequence comprises of initial intermolecular Heck coupling, followed by reduction of the carbonyl functionality of the Heck product and finally base-induced intramolecular condensation. Notably, the final condensation may proceed by an interesting oxy-Michael addition, cycloreversion via double bond isomerization and intramolecular condensation.

引用

页码：1245 / 1254

页数：10

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