Chimeric antigen receptor T-cell therapy for multiple myeloma

被引：10

作者：

Hosen, Naoki ^{[1
]}

机构：

[1] Osaka Univ, Dept Canc Stem Cell Biol, Grad Sch Med, 2-2 Yamada Oka, Suita, Osaka 5650871, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2020年 / 111卷 / 04期

关键词：

Chimeric antigen receptor; T cell; Multiple myeloma; Integrin; Protein conformation; MATURATION ANTIGEN; REMISSIONS; TARGET;

D O I：

10.1007/s12185-020-02827-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chimeric antigen receptor (CAR) T cell therapy, an immunotherapy using gene-modified T cells, has recently made a big success. CAR T cells targeting CD19 is highly effective against B cell malignancies. Next good target for CAR T therapy is multiple myeloma. B cell maturation antigen has been proved to be a good target for CAR T cell therapy in early-phase clinical trials. We are also developing CAR T cells targeting a protein conformation that is preferentially detected in myeloma cells. In this review, I will summarize the state of art in the field of CAR T cell therapy against myeloma, and also present our effort to develop a new CAR T cell therapy.

引用

页码：530 / 534

页数：5

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