The global epidemic of SARS-CoV-2 variants and their mutational immune escape

被引：82

作者：

Tian, Dandan ^{[1
]}

Sun, YanHong ^{[1
]}

Zhou, JianMing ^{[1
]}

Ye, Qing ^{[1
]}

机构：

[1] Zhejiang Univ, Natl Clin Res Ctr Child Hlth, Natl Childrens Reg Med Ctr, Dept Clin Lab,Childrens Hosp,Sch Med, Hangzhou, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2022年 / 94卷 / 03期

关键词：

COVID-19; immune escape; mutations; SARS-CoV-2; variants; ACUTE RESPIRATORY SYNDROME; VIRAL INFECTIVITY; SPIKE; CORONAVIRUS; VACCINE; ACE2; NEUTRALIZATION; RECOMBINATION; REPLICATION; MECHANISMS;

D O I：

10.1002/jmv.27376

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

During the COVID-19 pandemic, genetic variants of SARS-CoV-2 have been emerging and spreading around the world. Several SARS-CoV-2 endemic variants were found in United Kingdom, South Africa, Japan, and India between 2020 and April 2021. Studies have shown that many SARS-CoV-2 variants are more infectious than early wild strain and produce immune escape. These SARS-CoV-2 variants have brought new challenges to the prevention and control of COVID-19. This review summarizes and analyzes the biological characteristics of different amino acid mutations and the epidemic characteristics and immune escape of different SARS-CoV-2 variants. We hope to provide scientific reference for the monitoring, prevention, and control measures of new SARS-CoV-2 variants and the development strategy of the second-generation vaccine.

引用

页码：847 / 857

页数：11

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