Sense of purpose in life and inflammation in healthy older adults: A longitudinal study

被引：16

作者：

Guimond, Anne-Josee ^{[1
,2
,3
]}

Shiba, Koichiro ^{[1
,4
,5
]}

Kim, Eric S. ^{[1
,2
,3
,5
,6
]}

Kubzansky, Laura D. ^{[1
,2
,3
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02215 USA

[2] Harvard TH Chan Sch Publ Hlth, Lee Kum Sheung Ctr Hlth & Happiness, Boston, MA 02215 USA

[3] Harvard TH Chan Sch Publ Hlth, Boston, MA 02215 USA

[4] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA

[5] Harvard Univ, Human Flourishing Program, Inst Quantitat Social Sci, Cambridge, MA 02138 USA

[6] Univ British Columbia, Dept Psychol, Vancouver, BC, Canada

来源：

PSYCHONEUROENDOCRINOLOGY | 2022年 / 141卷

关键词：

Purpose in life; Inflammation; C-reactive protein; Health psychology; Epidemiology; Longitudinal Studies; ALL-CAUSE MORTALITY; C-REACTIVE PROTEIN; SOCIOECONOMIC-STATUS; ALZHEIMER-DISEASE; WELL; ASSOCIATION; INTERLEUKIN-6; SENSITIVITY; DEPRESSION; BEHAVIORS;

D O I：

10.1016/j.psyneuen.2022.105746

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: A higher sense of purpose in life has been linked with reduced risk of age-related chronic health conditions that share elevated inflammation as a key risk factor (e.g., neurodegenerative diseases, heart disease, and diabetes). While prior research has documented cross-sectional associations between higher sense of purpose and lower inflammation, few studies have examined the association between purpose and changes in inflammation over time. Objective: We tested if a higher sense of purpose was prospectively associated with lower likelihood of developing unhealthy C-reactive protein levels in older adults who initially had healthy CRP levels (i.e., <3 ug/mL). Methods: Participants were 6925 adults aged > 50 in the Health and Retirement Study who were followed for 8 years. Participants completed the purpose in life subscale of the Ryff Psychological Well-being Scales at study baseline in 2006/2008. CRP was obtained from blood spots collected at baseline and after 4 and 8 years of follow-up. Pooled logistic regression estimated discrete-time hazard ratios (HR) and 95% confidence intervals (CI) for the association between baseline purpose and onset of unhealthy CRP levels (>3 ug/mL). Results: There was no strong evidence of an association between baseline continuous purpose scores and onset of unhealthy CRP levels over time in the overall analytic sample. In sex-stratified models, higher purpose was associated with lower hazards of developing unhealthy CRP levels among men, while associations were null in women (e.g., in sociodemographics-adjusted model, men: HR=0.89, 95% CI: 0.79-0.99; women: HR=0.96, 95% CI: 0.85-1.08; interaction between continuous purpose scores and sex p = 0.15). Conclusions: Findings suggest that a higher versus lower sense of purpose is associated with lower inflammation levels in older men. In specific populations, purpose may serve as a novel target for future interventions aimed at reducing inflammation

引用

页数：9

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[1] C-reactive protein gene variants: independent association with late-life depression and circulating protein levels [J].