ANTIBACTERIAL AND CENTRAL NERVOUS SYSTEM ACTIVITY OF (4,5-DIARYL-4H-1,2,4-TRIAZOL-3-YL)METHACRYLIC ACID DERIVATIVES

被引：0

作者：

Paprocka, Renata ^{[1
]}

Modzelewska-Banachiewicz, Bozena ^{[1
]}

Kutkowska, Jolanta ^{[2
]}

Pawlowski, Kamil ^{[3
]}

Piatkowska-Chmiel, Iwona ^{[3
]}

Jagiello-Wojtowicz, Ewa ^{[3
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Dept Organ Chem, Fac Pharm, A Jurasza 2, PL-85089 Bydgoszcz, Poland

[2] Marie Curie Sklodowska Univ, Dept Genet & Microbiol, Akad 19, PL-20033 Lublin, Poland

[3] Med Univ, Dept Toxicol, Chodzki 8, PL-20093 Lublin, Poland

来源：

ACTA POLONIAE PHARMACEUTICA | 2017年 / 74卷 / 01期

关键词：

triazoles; methacrylic acid; propenoic acid; antibacterial activity; CNS activity; ANTIDEPRESSANT; DESIGN; AGENTS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The series of l,2,4-triazole derivatives containing methacrylic acid moiety were synthesized in reaction of N-3-substituted amidrazones with itaeonic anhydride. Preliminary calculated bioavailability parameters of obtained compounds suggested good penetration era cell membranes and their good absorption after oral intake. Antimicrobial evaluation in tint, showed diverse activity of obtained triazoles mainly on Grant-positive bacterial strains. One derivative was also examined to determine the effect on the central nervous system of mice.

引用

页码：289 / 292

页数：4

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