Detecting Reaction Intermediates in Liquids on the Millisecond Time Scale Using Desorption Electrospray Ionization

被引：116

作者：

Perry, Richard H. ^{[1
]}

Splendore, Maurizio

Chien, Allis

Davis, Nick K. ^{[1
]}

Zare, Richard N. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 01期

关键词：

mass spectrometry; organometallic catalysis; reaction intermediates; ruthenium; transfer hydrogenation; ASYMMETRIC TRANSFER HYDROGENATION; TANDEM MASS-SPECTROMETRY; HIGH-THROUGHPUT ANALYSIS; AMINO ALCOHOL; GAS-PHASE; KETONES; MECHANISM; RUTHENIUM(II); COMPLEXES; CATALYSTS;

D O I：

10.1002/anie.201004861

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Capturing transient species: The bombardment of a surface-bound Ru II complex with charged droplets containing a ligand allows the detection of reaction intermediates (see figure). The reaction investigated is used to synthesize RuII catalysts containing amino alcohol ligands, which facilitate the asymmetric transfer hydrogenation of ketones and imines. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：250 / 254

页数：5

共 65 条

[1]

[Anonymous], 2003, ANGEW CHEM, DOI DOI 10.1002/ANGE.200200560

[2] Non-Aqueous Spray Solvents and Solubility Effects in Desorption Electrospray Ionization [J].