Signaling of the Purinergic System in the Joint

被引:15
作者
Corciulo, Carmen [1 ,2 ]
Cronstein, Bruce N. [1 ,3 ]
机构
[1] NYU, Sch Med, Dept Med, Div Translat Med, New York, NY 10016 USA
[2] Univ Gothenburg, Inst Med, Dept Internal Med & Clin Nutr, Krefting Res Ctr, Gothenburg, Sweden
[3] NYU, Sch Med, Dept Med, Div Rheumatol, New York, NY 10016 USA
关键词
adenosine; cartilage; bone; synovium; tendon; purine; adenosine triphosphate; adenosine diphosphate; A(3) ADENOSINE RECEPTOR; MESENCHYMAL STEM-CELLS; HUMAN ARTICULAR CHONDROCYTES; INDUCED ATP RELEASE; FORMATION IN-VIVO; RHEUMATOID-ARTHRITIS; BONE-FORMATION; EXTRACELLULAR ATP; NUCLEOTIDE RECEPTORS; P2X(7) RECEPTOR;
D O I
10.3389/fphar.2019.01591
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body. All the joints have a similar composition including cartilage for reducing the friction of the movement and protecting the underlying bone, a synovial membrane that produces synovial fluid to lubricate the joint, ligaments to limit joint movement, and tendons for the interaction with muscles. Direct or indirect damage of one or more of the tissues forming the joint is the foundation of different pathological conditions. Many molecular mechanisms are involved in maintaining the joint homeostasis as well as in triggering disease development. The molecular pathway activated by the purinergic system is one of them. The purinergic signaling defines a group of receptors and intermembrane channels activated by adenosine, adenosine diphosphate, adenosine 5'-triphosphate, uridine triphosphate, and uridine diphosphate. It has been largely described as a modulator of many physiological and pathological conditions including rheumatic diseases. Here we will give an overview of the purinergic system in the joint describing its expression and function in the synovium, cartilage, ligament, tendon, and bone with a therapeutic perspective.
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页数:12
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共 165 条
[1]   International union of pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy [J].
Abbracchio, Maria P. ;
Burnstock, Geoffrey ;
Boeynaems, Jean-Marie ;
Barnard, Eric A. ;
Boyer, Jose L. ;
Kennedy, Charles ;
Knight, Gillian E. ;
Fumagalli, Marta ;
Gachet, Christian ;
Jacobson, Kenneth A. ;
Weisman, Gary A. .
PHARMACOLOGICAL REVIEWS, 2006, 58 (03) :281-341
[2]   The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro [J].
Agrawal, Ankita ;
Buckley, Katherine A. ;
Bowers, Keith ;
Furber, Mark ;
Gallagher, James A. ;
Gartland, Alison .
PURINERGIC SIGNALLING, 2010, 6 (03) :307-315
[3]   Synovial cellular and molecular markers in rheumatoid arthritis [J].
Amin, M. Asif ;
Fox, David A. ;
Ruth, Jeffrey H. .
SEMINARS IN IMMUNOPATHOLOGY, 2017, 39 (04) :385-393
[4]  
Anderson B. W., 2019, ANATOMY APPENDICULAR
[5]  
[Anonymous], PHYSL BONE REMODELIN
[6]   ATP and UTP stimulate bone morphogenetic protein-2,-4 and-5 gene expression and mineralization by rat primary osteoblasts involving PI3K/AKT pathway [J].
Ayala-Pena, Victoria B. ;
Scolaro, Luis A. ;
Santillan, Graciela E. .
EXPERIMENTAL CELL RESEARCH, 2013, 319 (13) :2028-2036
[7]   Pannexin membrane channels are mechanosensitive conduits for ATP [J].
Bao, L ;
Locovei, S ;
Dahl, G .
FEBS LETTERS, 2004, 572 (1-3) :65-68
[8]   Induction of an Antiinflammatory Effect and Prevention of Cartilage Damage in Rat Knee Osteoarthritis by CF101 Treatment [J].
Bar-Yehuda, S. ;
Rath-Wolfson, L. ;
Del Valle, L. ;
Ochaion, A. ;
Cohen, S. ;
Patoka, R. ;
Zozulya, G. ;
Barer, F. ;
Atar, E. ;
Pina-Oviedo, S. ;
Perez-Liz, G. ;
Castel, D. ;
Fishman, P. .
ARTHRITIS AND RHEUMATISM, 2009, 60 (10) :3061-3071
[9]   Contribution of Infrapatellar Fat Pad and Synovial Membrane to Knee Osteoarthritis Pain [J].
Belluzzi, Elisa ;
Stocco, Elena ;
Pozzuoli, Assunta ;
Granzotto, Marnie ;
Porzionato, Andrea ;
Vettor, Roberto ;
De Caro, Raffaele ;
Ruggieri, Pietro ;
Ramonda, Roberta ;
Rossato, Marco ;
Favero, Marta ;
Macchi, Veronica .
BIOMED RESEARCH INTERNATIONAL, 2019, 2019
[10]   Effects of adenosine on bacterial lipopolysaccharide- and interleukin 1-induced nitric oxide release from equine articular chondrocytes [J].
Benton, HP ;
MacDonald, MH ;
Tesch, AM .
AMERICAN JOURNAL OF VETERINARY RESEARCH, 2002, 63 (02) :204-210