Prevalence of Plasmodium spp. in illegal gold miners in French Guiana in 2015: a hidden but critical malaria reservoir

被引:74
作者
Douine, Maylis [1 ,2 ]
Musset, Lise [3 ]
Corlin, Florine [1 ]
Pelleau, Stephane [3 ]
Pasquier, Jeremie [4 ]
Mutricy, Louise [1 ]
Adenis, Antoine [1 ,2 ]
Djossou, Felix [5 ]
Brousse, Paul [6 ]
Perotti, Frederique [7 ]
Hiwat, Helene [8 ]
Vreden, Stephen [9 ]
Demar, Magalie [2 ,4 ]
Nacher, Mathieu [1 ,2 ]
机构
[1] INSERM, CIC 1424, Ctr Invest Clin Antilles Guyane, Ctr Hosp Cayenne, Rue Flamboyant,BP 6006, F-97306 Cayenne, France
[2] Univ Guyane, Ecosyst Amazoniens & Pathol Tropicale, Equipe EA 3593, Cayenne, France
[3] Ctr Natl Reference Paludisme, Inst Pasteur Guyane, WHO Collaborating Ctr Surveillance Anti Malarial, Lab Parasitol, Cayenne, France
[4] Cayenne Hosp, Lab Hosp Univ Parasitol Mycol, Cayenne, France
[5] Cayenne Hosp, Infect & Trop Dis Dept, Cayenne, France
[6] Cayenne Hosp, Ctr Delocalises Prevent & Soins, Cayenne, France
[7] Ctr Hosp Ouest Guyanais, Pharm, St Laurent Du Maroni, France
[8] Minist Hlth, Malaria Programme, Paramaribo, Suriname
[9] Fdn Sci Res Suriname SWOS, Paramaribo, Suriname, Suriname
关键词
Malaria; Illegal gold mining; French Guiana; Guiana Shield; Malaria reservoir; REAL-TIME-PCR; ASYMPTOMATIC CARRIERS; VIVAX MALARIA; INFECTION; PARASITEMIA; STRATEGIES; OUTBREAK; AREAS;
D O I
10.1186/s12936-016-1367-6
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Malaria is endemic in French Guiana, an overseas territory of France on the Guiana Shield. Since 2005, notified malaria cases are decreasing. However, new data show that malaria affects many Brazilian gold miners working illegally in French Guiana, the majority of whom are not counted in official data. In addition, one major concern is the usual practice of improper self-treatment in this mining population, raising fear of the development of antimalarial resistance. This prospective study, conducted in 2015, aimed to estimate the prevalence of Plasmodium spp. in illegal gold miners working in French Guiana. Methods: The recruitment of gold miners was carried out in resting sites along the French Guiana-Suriname border, where they go for supplies, medical care or leisure. After recording agreement, three malaria diagnostic methods were performed: rapid diagnostic test, microscopy and PCR. Results: Among 421 persons recruited in the study, malaria prevalence, detected by nested-PCR, was 22.3 % (CI [18.3-26.3], n = 94/421) of which 84 % were asymptomatic. Conclusions: This significant malaria reservoir in a mobile and illegal population with difficult access to a health care system raises the threat of artemisinin resistance and puts the population of the Guiana Shield at risk of new transmission foci while countries of the region aim at malaria elimination. Even though French legislation may hamper dealing with this population, France must face the reality of malaria in illegal gold miners in order to meet its commitment to malaria elimination.
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页数:8
相关论文
共 40 条
[1]  
Alves FP, 2005, J MED ENTOMOL, V42, P777, DOI 10.1603/0022-2585(2005)042[0777:ACOPSA]2.0.CO
[2]  
2
[3]  
[Anonymous], 2009, Malaria Microscopy Quality Assurance Manual Version 1. Malaria Light Microscopy: Creating a Culture of Quality
[4]  
Ardillon V, 2015, BVS, V1, P16
[5]   Loop Mediated Isothermal Amplification (LAMP) Accurately Detects Malaria DNA from Filter Paper Blood Samples of Low Density Parasitaemias [J].
Aydin-Schmidt, Berit ;
Xu, Weiping ;
Gonzalez, Iveth J. ;
Polley, Spencer D. ;
Bell, David ;
Shakely, Deler ;
Msellem, Mwinyi I. ;
Bjorkman, Anders ;
Martensson, Andreas .
PLOS ONE, 2014, 9 (08)
[6]   Epidemiology of Disappearing Plasmodium vivax Malaria: A Case Study in Rural Amazonia [J].
Barbosa, Susana ;
Gozze, Amanda B. ;
Lima, Nathalia F. ;
Batista, Camilla L. ;
Bastos, Melissa da Silva ;
Nicolete, Vanessa C. ;
Fontoura, Pablo S. ;
Goncalves, Raquel M. ;
Viana, Susana Ariane S. ;
Menezes, Maria Jose ;
Scopel, Kezia Katiani G. ;
Cavasini, Carlos E. ;
Malafronte, Rosely dos Santos ;
da Silva-Nunes, Monica ;
Vinetz, Joseph M. ;
Castro, Marcia C. ;
Ferreira, Marcelo U. .
PLOS NEGLECTED TROPICAL DISEASES, 2014, 8 (08)
[7]   Investigation of a Sudden Malaria Outbreak in the Isolated Amazonian Village of Saul, French Guiana, January-April 2009 [J].
Berger, Franck ;
Flamand, Claude ;
Musset, Lise ;
Djossou, Felix ;
Rosine, Jacques ;
Sanquer, Marie-Anne ;
Dusfour, Isabelle ;
Legrand, Eric ;
Ardillon, Vanessa ;
Rabarison, Patrick ;
Grenier, Claire ;
Girod, Romain .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2012, 86 (04) :591-597
[8]   Asymptomatic malaria infections: detectability, transmissibility and public health relevance [J].
Bousema, Teun ;
Okell, Lucy ;
Felger, Ingrid ;
Drakeley, Chris .
NATURE REVIEWS MICROBIOLOGY, 2014, 12 (12) :833-840
[9]   Mosquito Feeding Assays to Determine the Infectiousness of Naturally Infected Plasmodium falciparum Gametocyte Carriers [J].
Bousema, Teun ;
Dinglasan, Rhoel R. ;
Morlais, Isabelle ;
Gouagna, Louis C. ;
van Warmerdam, Travis ;
Awono-Ambene, Parfait H. ;
Bonnet, Sarah ;
Diallo, Mouctar ;
Coulibaly, Mamadou ;
Tchuinkam, Timoleon ;
Mulder, Bert ;
Targett, Geoff ;
Drakeley, Chris ;
Sutherland, Colin ;
Robert, Vincent ;
Doumbo, Ogobara ;
Toure, Yeya ;
Graves, Patricia M. ;
Roeffen, Will ;
Sauerwein, Robert ;
Birkett, Ashley ;
Locke, Emily ;
Morin, Merribeth ;
Wu, Yimin ;
Churcher, Thomas S. .
PLOS ONE, 2012, 7 (08)
[10]   History of malaria research and its contribution to the malaria control success in Suriname: a review [J].
Breeveld, Florence J. V. ;
Vreden, Stephen G. S. ;
Grobusch, Martin P. .
MALARIA JOURNAL, 2012, 11