Perinatal factors and risk of breast cancer

被引：176

作者：

Sanderson, M

Williams, MA

Malone, KE

Stanford, JL

Emanuel, I

White, E

Daling, JR

机构：

[1] Division of Public Health Sciences, Fred Hutchinson Cancer Res. Center, University of Washington, Seattle, WA

[2] Department of Epidemiology, University of Washington, Seattle, WA

[3] Maternal and Child Health Program, University of Washington, Seattle, WA

[4] Fred Hutchinson Cancer Res. Center, Seattle, WA 98104

来源：

EPIDEMIOLOGY | 1996年 / 7卷 / 01期

关键词：

breast cancer; perinatal factors; estrogen; intrauterine exposures;

D O I：

10.1097/00001648-199601000-00007

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A high level of endogenous estrogen in utero has been hypothesized to be a possible risk factor for breast cancer. We used information from two population-based case-control studies to investigate the relation between perinatal factors and risk of invasive breast cancer among women age 21-45 years (746 cases, 960 controls) and women age 50-64 years (401 cases, 439 controls). Breast cancer cases were ascertained through a population-based cancer registry, and controls were selected by random digit dialing. After adjustment for age, menopausal status, and maternal smoking, the birthweight-breast cancer association in women age 21-45 years followed a J-shaped curve, with women whose birthweight was less than 2,500 gm [odds ratio (OR) = 1.3; 95% confidence interval (CI) = 0.9-2.0] and 4,000 gm or more (OR = 1.7; 95% CI = 1.1-2.5) at increased risk. Women age 50-64 years who were 4,000 gm or more at birth appeared to be at slightly reduced risk of breast cancer (OR = 0.6; 95% CI = 0.3-1.1). With the exception of maternal smoking, there was little effect of other perinatal factors on breast cancer risk in either group. These results support the hypothesized association between intrauterine estrogen exposure and subsequent risk of breast cancer.

引用

页码：34 / 37

页数：4

共 38 条

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