Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials

被引：177

作者：

Holden, Patricia A. ^{[1
,2
]}

Gardea-Torresdey, Jorge L. ^{[2
,3
]}

Klaessig, Fred ^{[2
,4
]}

Turco, Ronald F. ^{[5
]}

Mortimer, Monika ^{[1
,2
,6
]}

Hund-Rinke, Kerstin ^{[7
]}

Hubal, Elaine A. Cohen ^{[8
]}

Avery, David ^{[2
]}

Barcelo, Damia ^{[9
,10
]}

Behra, Renata ^{[11
,12
]}

Cohen, Yoram ^{[2
,13
]}

Deydier-Stephan, Laurence ^{[14
]}

Ferguson, P. Lee ^{[15
]}

Fernandes, Teresa F. ^{[16
]}

Harthorn, Barbara Herr ^{[2
,17
]}

Henderson, W. Matthew ^{[18
]}

Hoke, Robert A. ^{[19
]}

Hristozov, Danail ^{[20
]}

Johnston, John M. ^{[18
]}

Kane, Agnes B. ^{[21
]}

Kapustka, Larry ^{[22
]}

Keller, Arturo A. ^{[1
,2
]}

Lenihan, Hunter S. ^{[1
,2
]}

Lovell, Wess ^{[23
]}

Murphy, Catherine J. ^{[24
]}

Nisbet, Roger M. ^{[2
,25
]}

Petersen, Elijah J. ^{[26
]}

Salinas, Edward R. ^{[27
]}

Scheringer, Martin ^{[28
]}

Sharma, Monita ^{[29
]}

Speed, David E. ^{[30
]}

Sultan, Yasir ^{[31
]}

Westerhoff, Paul ^{[32
]}

White, Jason C. ^{[33
]}

Wiesner, Mark R.

Wong, Eva M. ^{[34
]}

Xing, Baoshan ^{[35
]}

Horan, Meghan Steele ^{[2
]}

Godwin, Hilary A. ^{[2
,13
,36
,37
]}

Nel, Andre E. ^{[2
,13
,38
]}

机构：

[1] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA

[2] Univ Calif Los Angeles, UC CEIN, Los Angeles, CA 90095 USA

[3] Univ Texas El Paso, Environm Sci & Engn PhD Program, Dept Chem, El Paso, TX 79968 USA

[4] Penn Bio Nano Syst, Doylestown, PA 18901 USA

[5] Purdue Univ, Coll Agr, Soil Microbiol Lab, W Lafayette, IN 47907 USA

[6] NICPB, Lab Environm Toxicol, Akad Tee 23, EE-12618 Tallinn, Estonia

[7] Fraunhofer Inst Mol Biol & Appl Ecol, D-57392 Schmallenberg, Germany

[8] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA

[9] Inst Environm Assessment & Water Res IDAEA CSIC, Dept Environm Chem, Barcelona 08034, Spain

[10] Univ Girona, ICRA, Parc Cient & Tecnol, Girona 17003, Spain

[11] Eawag, Swiss Fed Inst Aquat Sci & Technol, CH-8600 Dubendorf, Switzerland

[12] ETH, Inst Biogeochem & Pollutant Dynam, CH-8092 Zurich, Switzerland

[13] Univ Calif Los Angeles, Calif NanoSyst Inst, Chem & Biomol Engn Dept, Los Angeles, CA 90095 USA

[14] European Chem Agcy ECHA, Annankatu 18, Helsinki 00121, Finland

[15] Duke Univ, Dept Civil & Environm Engn, CEINT, Durham, NC 27708 USA

[16] Heriot Watt Univ, Edinburgh EH14 4AS, Midlothian, Scotland

[17] Univ Calif Santa Barbara, Dept Anthropol, Ctr Nanotechnol Soc, Santa Barbara, CA 93106 USA

[18] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA

[19] EI du Pont de Nemours & Co, Newark, DE 19711 USA

[20] Univ Ca Foscari Venice, Dept Environm Sci Informat & Stat, I-30123 Venice, Italy

[21] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA

[22] LK Consultancy, Turner Valley, AB T0L 2A0, Canada

[23] Vive Crop Protect Inc, Toronto, ON M5G 1L6, Canada

[24] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[25] Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA

[26] NIST, Biosyst & Biomat Div, Mat Measurement Lab, Gaithersburg, MD 20899 USA

[27] BASF SE, Expt Toxicol & Ecol, D-67056 Ludwigshafen, Germany

[28] ETH, Inst Chem & Bioengn, CH-8093 Zurich, Switzerland

[29] PETA Int Sci Consortium Ltd, London N1 9RL, England

[30] Corp EHS, Globalfoundries, Hopewell Jct, NY 12533 USA

[31] Environm & Climate Change Canada, Gatineau, PQ K1A 0H3, Canada

[32] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA

[33] Connecticut Agr Expt Stn, Dept Analyt Chem, New Haven, CT 06504 USA

[34] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA

[35] Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA

[36] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90095 USA

[37] Univ Calif Los Angeles, Inst Environm & Sustainabil, Los Angeles, CA 90095 USA

[38] Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90095 USA

来源：

ENVIRONMENTAL SCIENCE & TECHNOLOGY | 2016年 / 50卷 / 12期

基金：

美国国家科学基金会;

关键词：

WALLED CARBON NANOTUBES; TITANIUM-DIOXIDE NANOPARTICLES; WASTE-WATER TREATMENT; CERIUM OXIDE NANOPARTICLES; COATED SILVER NANOPARTICLES; ECOTOXICITY TEST METHODS; AQUATIC TOXICITY TESTS; PARTICLE ICP-MS; TIO2; NANOPARTICLES; CEO2;

D O I：

10.1021/acs.est.6b00608

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain consequences including potential ecological effects. Various research communities view differently whether ecotoxicological testing of ENMs should be conducted using environmentally relevant concentrations where observing outcomes is difficult versus higher ENM doses, where responses are observable. What exposure conditions are typically used in assessing ENM hazards to populations? What conditions are used to test ecosystem-scale hazards? What is known regarding actual ENMs in the environment, via measurements or modeling simulations? How should exposure conditions, ENM transformation, dose, and body burden be used in interpreting biological and computational findings for assessing risks? These questions were addressed in the context of this critical review. As a result, three main recommendations emerged. First, researchers should improve ecotoxicology of ENMs by choosing test end points, duration, and study conditions-including ENM test concentrations that align with realistic exposure scenarios. Second, testing should proceed via tiers with iterative feedback that informs experiments at other levels of biological organization. Finally, environmental realism in ENM hazard assessments should involve greater coordination among ENM quantitative analysts, exposure modelers, and ecotoxicologists, across government, industry, and academia.

引用

页码：6124 / 6145

页数：22

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