Salmonella enterica Serovar Typhi and the Pathogenesis of Typhoid Fever

被引：198
作者：
Dougan, Gordon [1 ]
Baker, Stephen [2 ,3 ,4 ]
机构：
[1] Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Cambridge CB10 1SA, England
[2] Univ Oxford, Hosp Trop Dis, Wellcome Trust Major Overseas Program, Clin Res Unit, Ho Chi Minh City, Vietnam
[3] Univ Oxford, Ctr Trop Med, Oxford OX3 7FZ, England
[4] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England
来源：
ANNUAL REVIEW OF MICROBIOLOGY, VOL 68 | 2014年 / 68卷
基金：
英国惠康基金;
关键词：
enteric fever; typhoid; Salmonella Typhi; Salmonella Paratyphi A; CULTURED EPITHELIAL-CELLS; COMPLETE GENOME SEQUENCE; PARATYPHI-A; REDUCED SUSCEPTIBILITY; INTESTINAL INFLAMMATION; SEROTYPE TYPHIMURIUM; SELECTIVE CAPTURE; DRUG-RESISTANCE; HUMAN INFECTION; FLAGELLIN GENE;
D O I：
10.1146/annurev-micro-091313-103739
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Salmonella enterica serovar Typhi, the cause of typhoid, is host restricted to humans. S. Typhi has a monophyletic population structure, indicating that typhoid in humans is a relatively new disease. Antimicrobial usage is reshaping the current S. Typhi global population and may be driving the emergence of a specific haplotype, H58, that is well adapted to transmission in modern settings and is able to resist antimicrobial killing more efficiently than other S. Typhi. Evidence gathered through genomics and functional studies using the mouse and in vitro cell systems, together with clinical investigations, has provided insight into the mechanisms that underpin the pathogenesis of human typhoid and host restriction. Here we review the latest scientific advances in typhoid research and discuss how these novel approaches are changing our understanding of the disease.
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页码：317 / +
页数：9
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