Intracellular Ca2+ modulates Cl- current evoked by acetylcholine in Lymnaea neurons

被引：4

作者：

Vulfius, CA ^{[1
]}

Ryazansky, VD

Krasts, IV

Ilyasov, FE

机构：

[1] Russian Acad Sci, Inst Cell Biophys, Pushchino 142292, Moscow Region, Russia

[2] Pushchino State Univ, Pushchino 142292, Moscow Region, Russia

来源：

NEUROSCIENCE LETTERS | 1998年 / 249卷 / 01期

关键词：

nicotinic receptors; acetylcholine; Cl-; current; intracellular Ca2+; Lymnaea neurons; voltage-clamp;

D O I：

10.1016/S0304-3940(98)00338-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of voltage-gated Ca2+ current (I-Ca) on Cl- current (I-Cl) initiated by nicotinic receptors (AChRs) in dialysed voltage-clamped Lymnaea neurons was studied. Depolarising steps applied before or during ACh application decreased l(Cl) transiently and slowed down both the rising phase and decay of l(Cl). The effect of l(Ca) depended on the interval between l(Ca) and l(Cl); it was prevented by intracellular buffering with BAPTA or Ca2+ channel blocking with Ni2+. I-Sr had a similar action but the recovery was slower than after I-Ca; I-Ba was ineffective. The data suggest that inactivation of AChR channels is mediated by Ca2+ binding to a site in the AChR or the regulatory protein. (C) 1998 Published by Elsevier Science Ireland Ltd. Ail rights reserved.

引用

页码：5 / 8

页数：4

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