Neutrophil Elastase Inhibitors and Chronic Kidney Disease

被引：66

作者：

Bronze-da-Rocha, Elsa ^{[1
]}

Santos-Silva, Alice ^{[1
]}

机构：

[1] Univ Porto, Fac Farm, Dept Ciencias Biol, UCIBIO REQUIMTE,Lab Bioquim, P-4050313 Porto, Portugal

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2018年 / 14卷 / 10期

关键词：

End-stage renal disease (ESRD); chronic kidney disease (CKD); neutrophil elastase; neutrophil elastase inhibitors; inflammation; RECOMBINANT-HUMAN-ERYTHROPOIETIN; SERINE-PROTEASE INHIBITOR; RESPIRATORY-DISTRESS-SYNDROME; SEVERE CONGENITAL NEUTROPENIA; CLINICAL-PRACTICE GUIDELINE; RED-BLOOD-CELLS; EXTRACELLULAR TRAPS; HEMODIALYSIS-PATIENTS; THERAPEUTIC TARGETS; POLYMORPHONUCLEAR NEUTROPHILS;

D O I：

10.7150/ijbs.26111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

End-stage renal disease (ESRD), the last stage of chronic kidney disease (CKD), is characterized by chronic inflammation and oxidative stress. Neutrophils are the front line cells that mediate an inflammatory response against microorganisms as they can migrate, produce reactive oxygen species (ROS), secrete neutrophil serine proteases (NSPs), and release neutrophil extracellular traps (NETs). Serine proteases inhibitors regulate the activity of serine proteases and reduce neutrophil accumulation at inflammatory sites. This review intends to relate the role of neutrophil elastase in CKD and the effects of neutrophil elastase inhibitors in predicting or preventing inflammation.

引用

页码：1343 / 1360

页数：18

共 167 条

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