Future insights in fungal metabolic engineering

被引：39
作者：
Wakai, Satoshi [1 ]
Arazoe, Takayoshi [1 ]
Ogino, Chiaki [2 ]
Kondo, Akihiko [1 ,2 ]
机构：
[1] Kobe Univ, Grad Sch Sci Technol & Innovat, Nada Ku, 1-1 Rokkodai Cho, Kobe, Hyogo 6578501, Japan
[2] Kobe Univ, Grad Sch Engn, Dept Chem Sci & Engn, Nada Ku, 1-1 Rokkodai Cho, Kobe, Hyogo 6578501, Japan
来源：
BIORESOURCE TECHNOLOGY | 2017年 / 245卷
关键词：
Filamentous fungi; Metabolic engineering; Genome editing; Bioproduction; LACTIC ACID PRODUCTION; ASPERGILLUS-ORYZAE; FILAMENTOUS FUNGUS; MORTIERELLA-ALPINA; TRICHODERMA-REESEI; CULTURE-CONDITIONS; ARACHIDONIC-ACID; GENE-CLUSTER; HETEROLOGOUS PROTEINS; ENHANCED PRODUCTION;
D O I：
10.1016/j.biortech.2017.04.095
中图分类号：
S2 [农业工程];
学科分类号：
0828 ;
摘要：
Filamentous fungi exhibit versatile abilities, including organic acid fermentation, protein production, and secondary metabolism, amongst others, and thus have applications in the medical and food industries. Previous genomic analyses of several filamentous fungi revealed their further potential as host microorganisms for bioproduction. Recent advancements in molecular genetics, marker recycling, and genome editing could be used to alter transformation and metabolism, based on optimized design carbolated with computer science. In this review, we detail the current applications of filamentous fungi and describe modern molecular genetic tools that could be used to expand the role of these microorganisms in bioproduction. The present review shed light on the possibility of filamentous fungi as host microorganisms in the field of bioproduction in the future. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1314 / 1326
页数：13
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