Localized crystal-storing histiocytosis of the posterior fossa

被引:7
作者
Flanagan, Margaret E. [1 ]
Keene, Christopher Dirk [1 ]
Louis, David N. [2 ,3 ]
Juric-Sekhar, Gordana [1 ]
机构
[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
[2] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
[3] Harvard Med Sch, Boston, MA USA
关键词
central nervous system; crystal-storing histiocytosis; electron microscopy; intracellular crystals; lymphoplasmacytic neoplasm; NERVOUS-SYSTEM; PATIENT; GAMMOPATHY; DIAGNOSIS; DISORDER; WOMAN; MASS;
D O I
10.1111/neup.12486
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Crystal-storing histiocytosis (CSH) is an uncommon histiocytic proliferation reported to involve diverse organs and tissues, but involvement of the central nervous system (CNS) is rare. In most cases CSH is identified in association with underlying lymphoproliferative, plasma cell diseases or rarely with various inflammatory or infectious conditions. CSH is characterized by the cytoplasmic accumulation of crystalline material in histiocytes, most commonly of kappa immunoglobulin light chain. We report a unique case of localized CSH involving the left cerebellum and caudal brain stem in a young man with a history of gout but without known lymphoproliferative or plasma cell disorders. Awareness of this entity is important diagnostically, but also to ensure appropriate management and follow-up, particularly in the absence of apparent underlying malignancy.
引用
收藏
页码:529 / 534
页数:6
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