Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle

被引：66

作者：

Kitaoka, Yu ^{[1
]}

Takeda, Kohei ^{[2
]}

Tamura, Yuki ^{[1
]}

Hatta, Hideo ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Arts & Sci, Dept Sports Sci, Meguro Ku, 3-8-1 Komaba, Tokyo 1538902, Japan

[2] Univ Tsukuba, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki, Japan

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2016年 / 41卷 / 06期

基金：

日本学术振兴会;

关键词：

lactate; skeletal muscle; PGC-1; alpha; PDK4; UCP3; MITOCHONDRIAL BIOGENESIS; GENE-EXPRESSION; EXERCISE; METABOLISM; INTERVAL; CELLS; ACTIVATION; MECHANISM; ABUNDANCE; RECOVERY;

D O I：

10.1139/apnm-2016-0016

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

To examine the potential role of lactate as a signalling molecule in skeletal muscle, we performed global gene expression analysis of the mouse gastrocnemius muscle, 3 h after lactate administration using the Affymetrix GeneChip system (Affymetrix, Santa Clara, Calif., USA). Among the top 15 genes with the largest fold change, increased expression of Ppargc1a, Pdk4, and Ucp3 was confirmed using real-time quantitative polymerase chain reaction. Our findings suggest that lactate serves as a signal for upregulating genes related to mitochondrial function.

引用

页码：695 / 698

页数：4

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