Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment

被引：543

作者：

Wood, Laura D. ^{[1
,2
]}

Canto, Marcia Irene ^{[3
]}

Jaffee, Elizabeth M. ^{[4
]}

Simeone, Diane M. ^{[5
,6
]}

机构：

[1] Johns Hopkins Univ, Sol Goldman Pancreat Canc Res Ctr, Sch Med, Dept Pathol, CRB2 Room 345,1550 Orleans St, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sol Goldman Pancreat Canc Res Ctr, Sch Med, Dept Oncol, CRB2 Room 345,1550 Orleans St, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Dept Med, Div Gastroenterol & Hepatol, Sch Med, Baltimore, MD 21231 USA

[4] Johns Hopkins Univ, Sch Med, Bloomberg Kimmel Inst Canc Immunotherapy, Skip Viragh Ctr Pancreat Canc Res & Clin Care,Sid, Baltimore, MD 21231 USA

[5] NYU Langone Hlth, Perlmutter Canc Ctr, Dept Surg, New York, NY USA

[6] NYU Langone Hlth, Perlmutter Canc Ctr, Dept Pathol, New York, NY USA

来源：

GASTROENTEROLOGY | 2022年 / 163卷 / 02期

关键词：

Pancreatic Cancer; Pancreatic Ductal Adenocarci-noma; Cancer Screening; PAPILLARY-MUCINOUS NEOPLASM; MISMATCH REPAIR DEFICIENCY; HIGH-RISK INDIVIDUALS; PHASE-II TRIAL; INTRAEPITHELIAL NEOPLASIA; DUCTAL ADENOCARCINOMA; ABERRANT METHYLATION; TUMOR; GENE; MUTATIONS;

D O I：

10.1053/j.gastro.2022.03.056

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our understanding of the biology of PDAC have revealed new opportunities for early detection and targeted therapy of PDAC. In this review, we discuss the pathogenesis of PDAC, including molecular alterations in tumor cells, cellular alterations in the tumor microenvironment, and population-level risk factors. We review the current status of surveillance and early detection of PDAC, including populations at high risk and screening approaches. We outline the diagnostic approach to PDAC and highlight key treatment considerations, including how therapeutic approaches change with disease stage and targetable subtypes of PDAC. Recent years have seen significant improvements in our approaches to detect and treat PDAC, but large-scale, coordinated efforts will be needed to maximize the clinical impact for patients and improve overall survival.

引用

页码：386 / +

页数：18

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