Clinical significance of serum expression of GROβ in esophageal squamous cell carcinoma

被引：17

作者：

Dong, Qiao-Mei ^{[1
,2
]}

Zhang, Jin-Qiang ^{[1
,2
]}

Li, Qian ^{[1
,2
]}

Bracher, Jacqueline C. ^{[4
]}

Hendricks, Denver T. ^{[4
]}

Zhao, Xiao-Hang ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100021, Peoples R China

[2] Peking Union Med Coll, Beijing 100021, Peoples R China

[3] Navy Gen Hosp, Ctr Basic Med Sci, Beijing 100048, Peoples R China

[4] Univ Cape Town, Fac Hlth Sci, Div Med Biochem, ZA-7925 Cape Town, South Africa

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2011年 / 17卷 / 21期

基金：

中国国家自然科学基金;

关键词：

GRO beta; Esophageal squamous cell carcinoma; Metastasis; Cytokine; Tumor markers; CXC CHEMOKINES; CANCER CELLS; METASTASIS; PROLIFERATION; NEURONS; RISK;

D O I：

10.3748/wjg.v17.i21.2658

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To determine the association between serum levels of growth-related gene product beta (GRO beta) and clinical parameters in esophageal squamous cell carcinoma (ESCC). METHODS: Using enzyme-linked immunosorbent assay, serum GRO beta levels were measured in ESCC patients (n = 72) and healthy volunteers (n = 83). The association between serum levels of GRO beta and clinical parameters of ESCC was analyzed statistically. RESULTS: The serum GRO beta levels were much higher in ESCC patients than in healthy controls (median: 645 ng/L vs 269 ng/L, P < 0.05). Serum GRO beta levels were correlated positively with tumor size, lymph node metastasis, and tumor-node-metastasis (TNM) staging, but not with gender or the histological grade of tumors in ESCC patients. The sensitivity and specificity of the assay for serum GRO beta were 73.61% and 56.63%, respectively. CONCLUSION: GRO beta may function as an oncogene product and contribute to tumorigenesis and metastasis of ESCC. (C) 2011 Baishideng. All rights reserved.

引用

页码：2658 / 2662

页数：5

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