Glycosylation of 2-thiohydantoin derivatives. Synthesis of some novel S-alkylated and S-glucosylated hydantoins

被引：43

作者：

Khodair, AI ^{[1
]}

机构：

[1] Tanta Univ, Fac Educ, Dept Chem, Kafr El Sheikh Branch, Kafr El Sheikh, Egypt

来源：

CARBOHYDRATE RESEARCH | 2001年 / 331卷 / 04期

关键词：

3-aryl-2-thiohydantoins; 3-aryl-5-((Z)-arylidene)-2-(2-methylthioethyl)-2-thiohydantoins; 3-aryl-5-((Z)-arylidene)-2-(2; 3; 4; 6; '-tetra-; O-acetyl-beta-D-glucopyranosyl)-2-thiohydantoins; antiviral; antitumor agents;

D O I：

10.1016/S0008-6215(01)00040-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3-Aryl-5-((Z)-arylidene)-3-aryl-2-(2-methylthioethyl)-2-thiohydantoins 3a-f and 3-aryl-5-((Z)-arylidene)-2- (2',3',4',6'-tetra-O-acetyl-beta -D-glucopyranosyl)-2-thiohydantoins 7a-n were prepared from the reaction of 3-aryl-5-((Z)-arylidene)-2-thiohydantoins 2a-n with methylthioethyl chloride or 2',3',4',6'-tetra-O-acetyl-alpha -D-glucopyranosyl bromide via three different routes. The compounds did not display any antiviral and antitumoral activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：445 / 453

页数：9

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