Dependence of yield strain of human trabecular bone on anatomic site

被引:533
作者
Morgan, EF
Keaveny, TM
机构
[1] Univ Calif Berkeley, Dept Mech Engn, Orthopaed Biomech Lab, Berkeley, CA 94720 USA
[2] Univ Calif San Francisco, Dept Orthopaed Surg, San Francisco, CA 94143 USA
[3] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
关键词
cancellous bone; anatomic variation; yield strain; strength; biomechanics;
D O I
10.1016/S0021-9290(01)00011-2
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Understanding the dependence of human trabecular bone strength behavior on anatomic site provides insight into structure-function relationships and is essential to the increased success of site-specific finite element models of whole bones. To investigate the hypothesis that the yield strains of human trabecular bone depend on anatomic site, the uniaxial tensile and compressive yield properties were compared for cylindrical specimens from the vertebra (n = 61), proximal tibia (n = 31), femoral greater trochanter (n = 23), and femoral neck (n = 27) taken from 61 donors (67 +/- 15 years). Test protocols were used that minimized end artifacts and loaded specimens along the main trabecular orientation. Yield strains by site (mean +/- S.D.) ranged from 0.70 +/- 0.05% for the trochanter to 0.85 +/- 0.10% for the femoral neck in compression, from 0.61 +/- 0.05% for the trochanter to 0.70 +/- 0.05% for the vertebra in tension, and were always higher in compression than tension (p <0.001). The compressive yield strain was higher for the femoral neck than for all other sites (p <0.001). as was the tensile yield strain for the vertebra (p <0.007). Analysis of covariance, with apparent density as the covariate, indicated that inter-site differences existed in yield stress even after adjusting statistically for density (p <0.035). Coefficients of variation in yield strain within each site ranged from only 5-12%, consistent with the strong linear correlations (r(2) = 0.94-0.98) found between yield stress and modulus. These results establish that the yield strains of human trabecular bone can differ across sites, but that yield strain may be considered uniform within a given site despite substantial variation in elastic modulus and yield stress. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:569 / 577
页数:9
相关论文
共 37 条
[1]   Three-dimensional imaging of trabecular bone using the computer numerically controlled milling technique [J].
Beck, JD ;
Canfield, BL ;
Haddock, SM ;
Chen, TJH ;
Kothari, M ;
Keaveny, TM .
BONE, 1997, 21 (03) :281-287
[2]   MECHANICAL PROPERTY DISTRIBUTIONS IN THE CANCELLOUS BONE OF THE HUMAN PROXIMAL FEMUR [J].
BROWN, TD ;
FERGUSON, AB .
ACTA ORTHOPAEDICA SCANDINAVICA, 1980, 51 (03) :429-437
[3]   COMPRESSIVE BEHAVIOR OF BONE AS A 2-PHASE POROUS STRUCTURE [J].
CARTER, DR ;
HAYES, WC .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1977, 59 (07) :954-962
[4]   Uniaxial yield strains for bovine trabecular bone are isotropic and asymmetric [J].
Chang, WCW ;
Christensen, TM ;
Pinilla, TP ;
Keaveny, TM .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1999, 17 (04) :582-585
[5]   EVALUATION OF ORTHOGONAL MECHANICAL-PROPERTIES AND DENSITY OF HUMAN TRABECULAR BONE FROM THE MAJOR METAPHYSEAL REGIONS WITH MATERIALS TESTING AND COMPUTED-TOMOGRAPHY [J].
CIARELLI, MJ ;
GOLDSTEIN, SA ;
KUHN, JL ;
CODY, DD ;
BROWN, MB .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1991, 9 (05) :674-682
[6]   A cellular solid criterion for predicting the axial-shear failure properties of bovine trabecular bone [J].
Fenech, CM ;
Keaveny, TM .
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 1999, 121 (04) :414-422
[7]   Bone stiffness predicts strength similarly for human vertebral cancellous bone in compression and for cortical bone in tension [J].
Fyhrie, DP ;
Vashishth, D .
BONE, 2000, 26 (02) :169-173
[8]   PHYSICAL PROPERTIES OF TRABECULAR BONE [J].
GALANTE, J ;
ROSTOKER, W ;
RAY, RD .
CALCIFIED TISSUE RESEARCH, 1970, 5 (03) :236-&
[9]  
Gibson L.J., 1997, CAMBRIDGE SOLID STAT, V2nd, P510, DOI [10.1017/CBO9781139878326, DOI 10.1017/CBO9781139878326]
[10]   Direct three-dimensional morphometric analysis of human cancellous bone:: Microstructural data from spine, femur, iliac crest, and calcaneus [J].
Hildebrand, T ;
Laib, A ;
Müller, R ;
Dequeker, J ;
Rüegsegger, P .
JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (07) :1167-1174