Extramedullary T lymphoblastic transformation of chronic myeloid leukaemia occurring after double allogeneic transplantation

被引：9

作者：

Kell, J ^{[1
]}

Booth, M ^{[1
]}

Jones, B ^{[1
]}

Appleton, M ^{[1
]}

Lim, S ^{[1
]}

机构：

[1] Univ Wales Hosp, Dept Haematol, Cardiff CF4 4XN, S Glam, Wales

来源：

BONE MARROW TRANSPLANTATION | 1998年 / 22卷 / 08期

关键词：

chronic myeloid leukaemia; T lymphoblastic transformation; interleukin-2; allogeneic bone marrow transplantation; donor lymphocyte infusion;

D O I：

10.1038/sj.bmt.1701430

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The clinical course of chronic myeloid leukaemia (CML) is characterised by a chronic phase followed by an acute phase or blast crisis, Lymphoid transformation accounts for 20-30% of such events, with the majority of cases being of B cell origin. Extramedullary transformation occurs in approximately 10% of cases. We report a case of T cell lymphoblastic transformation in CML presenting as an extramedullary mass after allogeneic stem cell transplant. This case supports the growing evidence that CML arises in the pluripotent stem cell.

引用

页码：813 / 816

页数：4

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