A sequentially activated bioluminescent probe for observation of cellular H2O2 production induced by cysteine

被引：16
|
作者：
Ma, Kaiqing [1 ]
Yue, Yongkang [1 ]
Zhao, Lingling [1 ]
Chao, Jianbin [2 ]
Yin, Caixia [1 ]
机构：
[1] Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn,Minist Educ, Key Lab Mat Energy Convers & Storage Shanxi Prov, Taiyuan 030006, Peoples R China
[2] Shanxi Univ, Res Inst Appl Chem, Taiyuan 030006, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 78期
基金：
中国国家自然科学基金;
关键词：
HYDROGEN-PEROXIDE; METABOLISM; CHEMISTRY; BIOLOGY; MODEL; CYS;
D O I：
10.1039/d1cc04015d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report herein a caged luciferin probe Cy-Hy as a sequentially activated probe to selectively and sensitively sense l-Cys and H2O2. The probe displayed fluorescence and bioluminescence responses toward the two analytes. Utilizing the present probe, cellular excess l-Cys-induced H2O2 up-regulation was observed for the first time in living MDA-MB-231 cells.
引用
收藏
页码：10015 / 10018
页数：4
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