The Construction of Common and Specific Significance Subnetworks of Alzheimer's Disease from Multiple Brain Regions

被引:19
作者
Kong, Wei [1 ]
Mou, Xiaoyang [2 ]
Zhang, Na [1 ]
Zeng, Weiming [1 ]
Li, Shasha [3 ]
Yang, Yang [4 ]
机构
[1] Shanghai Maritime Univ, Informat Engn Coll, Shanghai 201306, Peoples R China
[2] DNJ Pharma & Rowan Univ, Glassboro, NJ 08028 USA
[3] Second Peoples Hosp Guizhou Prov, Dept Psychol, Guiyang 550004, Peoples R China
[4] Shanghai Jiao Tong Univ, Dept Comp Sci & Engn, Shanghai 200240, Peoples R China
关键词
GENE-EXPRESSION PROFILE; MAP KINASE; MITOCHONDRIAL DYSFUNCTION; NEUROFIBRILLARY TANGLES; GERMLINE MUTATIONS; SIGNALING PATHWAYS; PROTEIN; ACTIVATION; APOPTOSIS; SURVIVAL;
D O I
10.1155/2015/394260
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Alzheimer's disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions. The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insights for the pathogenetic mechanism of AD. In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions. Protein-protein interaction (PPI) data were integrated to add molecular biological information to construct the functional modules of six AD brain regions by Heinz algorithm. Then, the simulated annealing algorithm based on edge weight is applied to predicting and optimizing the maximal scoring networks for common and specific genes, respectively, which can remove the weak interactions and add the prediction of strong interactions to increase the accuracy of the networks. The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis. In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis.
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页数:13
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共 58 条
[51]  
SHERR CJ, 1992, CIBA F SYMP, V170, P209
[52]   PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas [J].
Sooman, Linda ;
Ekman, Simon ;
Tsakonas, Georgios ;
Jaiswal, Archita ;
Navani, Sanjay ;
Edqvist, Per-Henrik ;
Ponten, Fredrik ;
Bergstrom, Stefan ;
Johansson, Mikael ;
Wu, Xuping ;
Blomquist, Erik ;
Bergqvist, Michael ;
Gullbo, Joachim ;
Lennartsson, Johan .
TUMOR BIOLOGY, 2014, 35 (05) :4479-4488
[53]   The anatomy, physiology and functions of the perirhinal cortex [J].
Suzuki, WA .
CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (02) :179-186
[54]   Aldose Reductase-Mediated Phosphorylation of p53 Leads to Mitochondrial Dysfunction and Damage in Diabetic Platelets [J].
Tang, Wai Ho ;
Stitham, Jeremiah ;
Jin, Yu ;
Liu, Renjing ;
Lee, Seung Hee ;
Du, Jing ;
Atteya, Gourg ;
Gleim, Scott ;
Spollett, Geralyn ;
Martin, Kathleen ;
Hwa, John .
CIRCULATION, 2014, 129 (15) :1598-1609
[55]   ERK MAP kinase in G1 cell cycle progression and cancer [J].
Torii, Satoru ;
Yamamoto, Takuya ;
Tsuchiya, Yoshiki ;
Nishida, Eisuke .
CANCER SCIENCE, 2006, 97 (08) :697-702
[56]   Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein [J].
Uetsuki, T ;
Takemoto, K ;
Nishimura, I ;
Okamoto, M ;
Niinobe, M ;
Momoi, T ;
Miura, M ;
Yoshikawa, K .
JOURNAL OF NEUROSCIENCE, 1999, 19 (16) :6955-6964
[57]   XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions [J].
Vidal, AE ;
Boiteux, S ;
Hickson, AD ;
Radicella, JP .
EMBO JOURNAL, 2001, 20 (22) :6530-6539
[58]   Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer's Disease [J].
Wes, Paul D. ;
Easton, Amy ;
Corradi, John ;
Barten, Donna M. ;
Devidze, Nino ;
DeCarr, Lynn B. ;
Amy Truong ;
He, Aiqing ;
Barrezueta, Nestor X. ;
Polson, Craig ;
Bourin, Clotilde ;
Flynn, Marianne E. ;
Keenan, Stefanie ;
Lidge, Regina ;
Meredith, Jere ;
Natale, Joanne ;
Sankaranarayanan, Sethu ;
Cadelina, Greg W. ;
Albright, Charlie F. ;
Cacace, Angela M. .
PLOS ONE, 2014, 9 (08)