Household crowding in early adulthood and schizophrenia are unrelated in Denmark: a nested case-control study

被引:13
作者
Agerbo, E
Torrey, EF
Mortensen, PB
机构
[1] Univ Aarhus, Natl Ctr Register Based Res, DK-8000 Aarhus C, Denmark
[2] Stanley Fdn Res Program, Bethesda, MD 20814 USA
[3] Psychiat Hosp Aarhus, Dept Psychiat Demog, Inst Basic Psychiat Res, DK-8240 Risskov, Denmark
关键词
household crowding; risk factors; schizophrenia; urban birth;
D O I
10.1016/S0920-9964(00)00133-X
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
A number of studies have found that being born in an urban area is a risk factor for developing schizophrenia. It has been hypothesized that increased exposure to infectious agents through household crowding might account for this association. Using Danish longitudinal registers, we have established a population-based sample of 191 cases of schizophrenia where the first admission occurred between 1981 and 1993. These cases were compared with 17 413 individually matched controls of the same gender and age. Information regarding parents' and siblings' psychiatric history, urbanization, season and place of birth, and square meter per dweller were included in a conditional logistic regression model. We found square meter per dweller to be insignificant and without any trend when included as a risk factor for schizophrenia, whereas previous findings of schizophrenia associated with being born in an urban area and with schizophrenia in parents and siblings were replicated. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:243 / 246
页数:4
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