HIV Infection Induces Morphometrical Changes on the Oral (Buccal Mucosa and Tongue) Epithelial Cells

被引：0
作者：
Pompermayer, Adriane Bastos [2 ]
Dias Gil, Francisca Berenice
Sottile Franca, Beatriz Helena [2 ]
Naval Machado, Maria Angela [1 ]
Trevilatto, Paula Cristina [2 ]
Fernandes, Angela [1 ]
Soares de Lima, Antonio Adilson [1 ]
机构：
[1] Univ Fed Parana, Dept Estomatol, Curso Odontol, BR-80210170 Curitiba, Parana, Brazil
[2] Pontificia Univ Catolica Parana, Dept Stomatol, Sch Dent, Curitiba, Parana, Brazil
来源：
CURRENT HIV RESEARCH | 2011年 / 9卷 / 01期
关键词：
Exfoliative cytology; HIV; oral mucosa; oral squamous epithelium; IMMUNODEFICIENCY-VIRUS TYPE-1; VIRAL LOAD; LESIONS; SALIVA; HUMAN-HERPESVIRUS-8; KERATINOCYTES; TRANSMISSION; POPULATION; EXPOSURE; MEN;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aim of this study was to assess morphological and morphometrical alterations of oral squamous epithelial cells in type 1 HIV infected individuals. Oral smears were collected from tongue and buccal mucosa of 30 HIV infected (experimental) and 30 non-infected (control) individuals by liquid-based exfoliative cytology. The cells were morphologically analyzed and the nuclear area (NA), the cytoplasmic area (CA) and the nucleus-to-cytoplasm area ratio (NA/CA) were calculated. No morphological differences were found between the groups. The mean values of CA were decreased in tongue (P = .00006) and buccal mucosa (P = .00242) in HIV infected individual, while mean values of NA were increased (P = .00308 and .00095, respectively) in the same group. NA/CA ratio for experimental group was increased in both collected places, with P = .00001 (tongue) and P = .00000 (buccal mucosa). This study revealed that HIV infection was able to induce morphometrical changes on the oral epithelial cells.
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页码：11 / 16
页数：6
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