An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis

被引：112

作者：

McGregor, DB ^{[1
]}

Partensky, C ^{[1
]}

Wilbourn, J ^{[1
]}

Rice, JM ^{[1
]}

机构：

[1] Int Agcy Res Canc, F-69372 Lyon 08, France

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1998年 / 106卷

关键词：

aryl hydrocarbon receptor; cancer; carcinogenesis; carcinogenic mechanism; contaminated rice oil; dioxin; industrial exposure; polychlorinated dibenzofurans; polychlorinated dibenzo-p-dioxins; 2,3,7,8-tetrachlorodibenzo-p-dioxin;

D O I：

10.2307/3433830

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The International Agency for Research on Cancer (IARC) Monographs program reevaluated polychlorinated dibenzo-p-dioxins and evaluated polychlorinated dibenzofurans as possible carcinogenic hazards to humans in February 1997, using the most recent epidemiologic data on exposed human populations, experimental carcinogenicity bioassays in laboratory animals, and supporting evidence on relevant mechanisms of carcinogenesis. 2,3,7,8-Tetrachlorodibenzo-p- dioxin (TCDD) was evaluated as carcinogenic to humans (IARC group 1 classification) on the basis of limited evidence of carcinogenicity to humans derived from follow-up of workers who had been heavily exposed in industrial accidents and sufficient evidence of carcinogenicity in experimental animals. The evaluation also considered the following supporting evidence: TCDD is a multisite carcinogen in experimental animals and has been shown by several lines of evidence to act through a mechanism involving the aryl hydrocarbon receptor; this receptor is highly conserved in an evolutionary sense and functions the same way in humans as in experimental animals, tissue concentrations of TCDD are similar in heavily exposed human populations in which an increased overall cancer risk was observed and in exposed rats that developed tumors in carcinogenicity tests. Other polychlorinated dibenzo-p-dioxins, the nonchlorinated dibenzo-p dioxin, and polychlorinated dibenzofurans were evaluated as not classifiable as to their carcinogenicity to humans (group 3).

引用

页码：755 / 760

页数：6

共 48 条

[11] RELATIVE TOXICITY AND TUMOR-PROMOTING ABILITY OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD), 2,3,4,7,8-PENTACHLORODIBENZOFURAN (PCDF), AND 1,2,3,4,7,8-HEXACHLORODIBENZOFURAN (HCDF) IN HAIRLESS MICE [J].