The Long-Term Effectiveness and Safety of Cannabidiol-Enriched Oil in Children With Drug-Resistant Epilepsy

被引：5
作者：
Tzadok, Michal [1 ,2 ,3 ]
Hamed, Nasrin [1 ,2 ]
Heimer, Gali [1 ,2 ]
Zohar-Dayan, Efrat [1 ,2 ]
Rabinowicz, Shira [1 ,2 ]
Ben Zeev, Bruria [1 ,2 ]
机构：
[1] Edmond & Lily Safra Childrens Hosp, Sheba Med Ctr, Pediat Neurol Unit, Ramat Gan, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
[3] Edmond & Lily Safra Childrens Hosp, Sheba Med Ctr, Pediat Neurol Unit, IL-5262000 Ramat Gan, Israel
来源：
PEDIATRIC NEUROLOGY | 2022年 / 136卷
关键词：
Cannabidiol; Artisanal cannabis oil; Refractory epilepsy; Seizures; Long-term follow-up; PEDIATRIC EPILEPSY; ANTICONVULSANT; SEIZURES; EXTRACTS; CANNABINOIDS; MODELS; TRIAL; MOUSE;
D O I：
10.1016/j.pediatrneurol.2022.06.016
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Several retrospective studies on pediatric epilepsy reported positive effects of cannabidiol-enriched artisanal cannabis oil and pure cannabidiol oil on seizure reduction. Methods: This is a retrospective study of children and adolescents with refractory epilepsy caused by various etiologies who were treated with artisanal cannabis oil during January 2014 to June 2019, with at least one year follow-up. Results: Of 114 patients, 84 (73.3%) reported some improvement in seizure frequency at some point during treatment. Fifty-one (59%) of the 86 patients who continued treatment for at least one year showed >50% improvement in seizure frequency. Seizure etiology, seizure type, and patients' age and sex were not found to be associated with the response to cannabidiol-enriched cannabis oil. Side effects were minor, and positive effects beyond seizure reduction were noted. Conclusions: Artisanal cannabidiol-enriched cannabis may be an effective and safe long-term treatment for refractory epilepsy. (c) 2022 Elsevier Inc. All rights reserved.
引用
收藏
页码：15 / 19
页数：5
相关论文
共 30 条
[1]   Epilepsy and cannabidiol: a guide to treatment [J].
Arzimanoglou, Alexis ;
Brandi, Ulrich ;
Cross, J. Helen ;
Gil-Nagel, Antonio ;
Lagae, Lieven ;
Landmark, Cecilie Johannessen ;
Specchio, Nicola ;
Nabbout, Rima ;
Thiele, Elizabeth A. ;
Gubbay, Oliver .
EPILEPTIC DISORDERS, 2020, 22 (01) :1-14
[2]   Molecular Targets of Cannabidiol in Neurological Disorders [J].
Bih, Clementino Ibeas ;
Chen, Tong ;
Nunn, Alistair V. W. ;
Bazelot, Michael ;
Dallas, Mark ;
Whalley, Benjamin J. .
NEUROTHERAPEUTICS, 2015, 12 (04) :699-730
[3]   Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome [J].
Devinsky, Orrin ;
Patel, Anup D. ;
Thiele, Elizabeth A. ;
Wong, Matthew H. ;
Appleton, Richard ;
Harden, Cynthia L. ;
Greenwood, Sam ;
Morrison, Gilmour ;
Sommerville, Kenneth .
NEUROLOGY, 2018, 90 (14) :E1204-+
[4]   Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome [J].
Devinsky, Orrin ;
Patel, Anup D. ;
Cross, J. Helen ;
Villanueva, Vicente ;
Wirrell, Elaine C. ;
Privitera, Michael ;
Greenwood, Sam M. ;
Roberts, Claire ;
Checketts, Daniel ;
VanLandingham, Kevan E. ;
Zuberi, Sameer M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (20) :1888-1897
[5]   Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome [J].
Devinsky, Orrin ;
Cross, J. Helen ;
Laux, Linda ;
Marsh, Eric ;
Miller, Ian ;
Nabbout, Rima ;
Scheffer, Ingrid E. ;
Thiele, Elizabeth A. ;
Wright, Stephen .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (21) :2011-2020
[6]   Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial [J].
Devinsky, Orrin ;
Marsh, Eric ;
Friedman, Daniel ;
Thiele, Elizabeth ;
Laux, Linda ;
Sullivan, Joseph ;
Miller, Ian ;
Flamini, Robert ;
Wilfong, Angus ;
Filloux, Francis ;
Wong, Matthew ;
Tilton, Nicole ;
Bruno, Patricia ;
Bluvstein, Judith ;
Hedlund, Julie ;
Kamens, Rebecca ;
Maclean, Jane ;
Nangia, Srishti ;
Singhal, Nilika Shah ;
Wilson, Carey A. ;
Patel, Anup ;
Cilio, Maria Roberta .
LANCET NEUROLOGY, 2016, 15 (03) :270-278
[7]   Phytocannabinoids and epilepsy [J].
dos Santos, R. G. ;
Hallak, J. E. C. ;
Leite, J. P. ;
Zuardi, A. W. ;
Crippa, J. A. S. .
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2015, 40 (02) :135-143
[8]   Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment [J].
Englund, Amir ;
Morrison, Paul D. ;
Nottage, Judith ;
Hague, Dominic ;
Kane, Fergus ;
Bonaccorso, Stefania ;
Stone, James M. ;
Reichenberg, Avi ;
Brenneisen, Rudolf ;
Holt, David ;
Feilding, Amanda ;
Walker, Lucy ;
Murray, Robin M. ;
Kapur, Shitij .
JOURNAL OF PSYCHOPHARMACOLOGY, 2013, 27 (01) :19-27
[9]   Cannabinoids in the Treatment of Epilepsy [J].
Friedman, Daniel ;
Devinsky, Orrin .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (11) :1048-1058
[10]   Cannabidivarin is anticonvulsant in mouse and rat [J].
Hill, A. J. ;
Mercier, M. S. ;
Hill, T. D. M. ;
Glyn, S. E. ;
Jones, N. A. ;
Yamasaki, Y. ;
Futamura, T. ;
Duncan, M. ;
Stott, C. G. ;
Stephens, G. J. ;
Williams, C. M. ;
Whalley, B. J. .
BRITISH JOURNAL OF PHARMACOLOGY, 2012, 167 (08) :1629-1642
123