Is prostate cancer screening responsible for the negative results of prostate cancer treatment trials?

被引：4

作者：

Prasad, Vinay ^{[1
,2
,3
]}

机构：

[1] Oregon Hlth & Sci Univ, Knight Canc Inst, Div Hematol Oncol, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Ctr Hlth Care Eth, Portland, OR 97239 USA

来源：

MEDICAL HYPOTHESES | 2016年 / 93卷

关键词：

RADICAL PROSTATECTOMY; ANDROGEN SUPPRESSION; RADIATION-THERAPY; MORTALITY; RADIOTHERAPY; MANAGEMENT; DISEASE; RISK;

D O I：

10.1016/j.mehy.2016.05.019

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Clinical guidelines continue to move away from routine prostate specific antigen screening (PSA), once a widespread medical practice. A curious difference exists between early prostate cancer and early breast cancer. While randomized trials of therapy in early breast cancer continue to show overall survival benefit, this is not the case in prostate cancer, where prostatectomy was no better than observation in a recent trial, and where early androgen deprivation is no better than late androgen deprivation. Here, I make the case that prostate cancer screening contributes so greatly to over diagnosis that even treatment trials yield null results due to contamination with non-life threatening disease. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：71 / 73

页数：3

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