Inflammatory bowel diseases, celiac disease, and bone

被引：44

作者：

Bianchi, Maria Luisa ^{[1
]}

机构：

[1] IRCCS, Bone Metab Unit, Ist Auxol Italian, I-20145 Milan, Italy

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2010年 / 503卷 / 01期

关键词：

Inflammatory bowel diseases; Crohn's disease; Ulcerative colitis; Celiac disease; Calcium; Vitamin D; Osteoporosis; Bone density; Fractures; GLUTEN-FREE DIET; VITAMIN-D METABOLITES; INTESTINAL CALCIUM-ABSORPTION; X-RAY ABSORPTIOMETRY; MINERAL DENSITY; CROHNS-DISEASE; BODY-COMPOSITION; RISK-FACTORS; PARATHYROID-HORMONE; PEDIATRIC-PATIENTS;

D O I：

10.1016/j.abb.2010.06.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The article summarizes the current knowledge on the pathogenesis, clinical aspects and treatment of bone problems in the major inflammatory bowel diseases (Crohn's disease and ulcerative colitis) and celiac disease. It presents the physiological relationship between intestine and bone as well as the alterations determined by disease-disrupted intestinal integrity. Two hypotheses about the pathogenetic mechanisms of bone metabolism derangements and bone loss are discussed: the classical one, that indicates calcium malabsorption as the main culprit, and the new one, that emphasizes the role of inflammation. The article summarizes the available epidemiological data about osteopenia/osteoporosis and fragility fractures in these chronic intestinal diseases and presents the state-of-the-art treatment options. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：54 / 65

页数：12

共 233 条

[1]

ADACHI JD, 1983, SEMIN ARTHRITS RHEUM, V22, P375

[2] Bone mineral assessment by dual energy X-ray Absorptiometry in children with inflammatory bowel disease: Evaluation by age or bone area [J].

Ahmed, SF ;

Horrocks, IA ;

Patterson, T ;

Zaidi, S ;

Ling, TC ;

McGrogan, T ;

Weaver, TT .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2004, 38 (03) :276-280

[3] Narrative review: Celiac disease: Understanding a complex autoimmune disorder [J].

Alaedini, A ;

Green, PHR .

ANNALS OF INTERNAL MEDICINE, 2005, 142 (04) :289-298

[4]

[Anonymous], 2003, Gastroenterology, V124, P791, DOI [10.1053/gast.2003, DOI 10.1053/GAST.2003]

[5] Altered bone metabolism in inflammatory bowel disease: there is a difference between Crohn's disease and ulcerative colitis [J].

Ardizzone, S ;

Bollani, S ;

Bettica, P ;

Bevilacqua, M ;

Molteni, P ;

Porro, GB .

JOURNAL OF INTERNAL MEDICINE, 2000, 247 (01) :63-70

[6] Effect of age and dietary calcium on intestinal calbindin D-9k expression in the rat [J].

Armbrecht, HJ ;

Boltz, MA ;

Bruns, MEH .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2003, 420 (01) :194-200

[7]

ARNAUD SB, 1975, P SOC EXP BIOL MED, V149, P570, DOI 10.3181/00379727-149-38853

[8] Long-term effect of gluten restriction on bone mineral density of patients with coeliac disease [J].

Bai, JC ;

Gonzalez, D ;

Mautalen, C ;

Mazure, R ;

Pedreira, S ;

Vazquez, H ;

Smecuol, E ;

Siccardi, A ;

Cataldi, M ;

Niveloni, S ;

Boerr, LA ;

Maurino, E .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 1997, 11 (01) :157-164

[9] Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption [J].

Balesaria, Sara ;

Sangha, Sonia ;

Walters, Julian R. F. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2009, 297 (06) :G1193-G1197

[10] Reduced bone mineral density after surgical treatment for obesity [J].

Bano, G ;

Rodin, DA ;

Pazianas, M ;

Nussey, SS .

INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (04) :361-365

← 1 2 3 4 5 6 7 8 9 10 →