Catalytic Alkyne Arylation Using Traceless Directing Groups

被引：16

作者：

Park, Jung-Woo ^{[1
,2
]}

Kang, Bubwoong ^{[1
]}

Dong, Vy M. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, 4403 Nat Sci 1, Irvine, CA 92697 USA

[2] Inst for Basic Sci Korea, Ctr Catalyt Hydrocarbon Functionalizat, Daejeon 34141, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 41期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

alkynes; aminoarylation; multicomponent coupling; palladium; regiocontrol; C-H ACTIVATION; ALPHA-ARYLATION; ATOM TRANSFER; HYDROAMINATION; ALKENES; HYDROARYLATION; HETEROCYCLES; CARBOAMINATION; KETONES; BONDS;

D O I：

10.1002/anie.201804955

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By using Pd-0/Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either alpha-arylphenones or alpha,alpha-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C-C bond formation.

引用

页码：13598 / 13602

页数：5

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