Enantioselective Synthesis of Optically Pure β-Amino Ketones and γ-Aryl Amines by Rh-Catalyzed Asymmetric Hydrogenation

被引：34

作者：

Geng, Huiling ^{[1
,2
,3
]}

Huang, Kexuan ^{[2
,3
]}

Sun, Tian ^{[2
,3
]}

Li, Wei ^{[2
,3
]}

Zhang, Xiaowei ^{[2
,3
]}

Zhou, Le ^{[1
]}

Wu, Wenjun ^{[1
]}

Zhang, Xumu ^{[2
,3
]}

机构：

[1] NW A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China

[2] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[3] Rutgers State Univ, Dept Pharmaceut Chem, Piscataway, NJ 08854 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 01期

基金：

美国国家卫生研究院;

关键词：

STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; CARBONYL-COMPOUNDS; CHEMOSELECTIVE HYDROGENATION; REDUCTION; ALCOHOLS; ACIDS; CHEMISTRY; LIGANDS; BENZYL;

D O I：

10.1021/jo102091f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of optically pure beta-amino ketones have been synthesized in high enantioselectivities (ee > 99%) by Rh-DuanPhos-catalyzed asymmetric hydrogenation of readily prepared beta-keto enamides. Further reduction of these beta-amino ketones with hydrogen and Pd/C leads to the formation of a variety of protected enantiomerically pure gamma-aryl amines (ee > 99%), which are key building blocks in many bioactive molecules.

引用

页码：332 / 334

页数：3

共 64 条

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