Detection of cortical activation with time-resolved diffuse optical methods

被引：48

作者：

Montcel, B ^{[1
]}

Chabrier, R ^{[1
]}

Poulet, P ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, Inst Biol Phys, UMR 7004, F-67085 Strasbourg, France

来源：

APPLIED OPTICS | 2005年 / 44卷 / 10期

关键词：

D O I：

10.1364/AO.44.001942

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Simulations based on diffusion theory that use a finite-element method and rely on an magnetic resonance imaging head model suggest that time-resolved diffuse optical techniques could provide information about the depth at which variations in per-fusion take place and improve the detection of cortical activation. Experimental investigations were performed with sequentially driven picosecond laser diodes and an eight-channel time-correlated single-photon-counting detection system. The experimental results obtained for activation in the motor cortex, and for the Valsalva maneuver, confirm our assumptions and are in good agreement with the simulated data. (c) 2005 Optical Society of America.

引用

页码：1942 / 1947

页数：6

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