Toll-like receptors signaling network in pre-eclampsia: An updated review

被引：49

作者：

Afkham, Amir ^{[1
]}

Eghbal-Fard, Shadi ^{[1
,2
]}

Heydarlou, Hanieh ^{[1
]}

Azizi, Ramyar ^{[1
]}

Aghebati-Maleki, Leili ^{[3
]}

Yousefi, Mehdi ^{[2
,4
]}

机构：

[1] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[4] Tabriz Univ Med Sci, Dept Immunol, Fac Med, POB 6446-14155, Tabriz, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 03期

关键词：

innate immunity; preeclampsia (PE); pregnancy; toll-like receptor (TLR); FETAL-MATERNAL INTERFACE; NORMAL-PREGNANCY; INFLAMMATORY RESPONSE; INNATE IMMUNITY; TROPHOBLAST RESPONSES; GENE POLYMORPHISMS; WORKING GROUP; EARLY-ONSET; EXPRESSION; ACTIVATION;

D O I：

10.1002/jcp.27189

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Toll-like receptors (TLRs) are innate immune cells receptors. They are expressed on leukocytes, epithelial cells, and more particularly on placental immune cells and chorion trophoblast. Upregulation of innate immune response occurs during normal pregnancy, but its excessive activity is involved in the pathology of pregnancy complications including pregnancy-induced hypertension and pre-eclampsia (PE). The recent studies about the overmuch inflammatory responses and aberrant placentation are associated with increased expression of TLRs in PE patients. This review has tried to focus on the relationship between some activities of TLRs and the risk of preeclampsia development.

引用

页码：2229 / 2240

页数：12

共 97 条

[1] TLR6 modulates first trimester trophoblast responses to peptidoglycan [J].