Anhydrous Conditions Enable the Catalyst-Free Carboxylation of Aromatic Alkynes with CO2 under Mild Conditions

被引：2

作者：

Toniolo, Davide ^{[1
]}

Bobbink, Felix D. ^{[1
]}

Dyson, Paul J. ^{[1
]}

Mazzanti, Marinella ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2020年 / 103卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

alkynes; carbon dioxide fixation; propiolic acids; C-H activation; cesium carbonate; C-H ACTIVATION; CARBON-DIOXIDE; TERMINAL ALKYNES; N-FORMYLATION; METHYLATION; MECHANISM; BONDS;

D O I：

10.1002/hlca.201900258

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct carboxylation of aromatic alkynes with CO2, a cheap and widely available C1 source, is the most attractive method for the synthesis of carboxylic acids. Here we show that direct carboxylation of terminal alkynes can be simply performed in near-quantitative yield in four hours with anhydrous Cs2CO3 under mild conditions without need of a metal catalyst.

引用

页数：6

共 32 条

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