Gene expression of NOX family members and their clinical significance in hepatocellular carcinoma

被引：48

作者：

Eun, Hyuk Soo ^{[1
,2
]}

Cho, Sang Yeon ^{[3
]}

Joo, Jong Seok ^{[1
,2
]}

Kang, Sun Hyung ^{[1
,2
]}

Moon, Hee Seok ^{[1
,2
]}

Lee, Eaum Seok ^{[1
,2
]}

Kim, Seok Hyun ^{[1
,2
]}

Lee, Byung Seok ^{[1
,2
]}

机构：

[1] Chungnam Natl Univ Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, 282 Munwha Ro, Daejeon, South Korea

[2] Chungnam Natl Univ, Sch Med, Dept Internal Med, 266 Munwha Ro, Daejeon, South Korea

[3] Chungnam Natl Univ, Sch Med, 266 Munwha Ro, Daejeon, South Korea

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

新加坡国家研究基金会;

关键词：

FC-GAMMA RECEPTORS; NADPH OXIDASE 4; OXIDATIVE STRESS; CANCER; INFLAMMATION; IL6; ROS;

D O I：

10.1038/s41598-017-11280-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex-derived reactive oxygen species (ROS) promote chronic liver inflammation and remodeling that can drive hepatocellular carcinoma development. The role of NOX expression in hepatocellular carcinoma (HCC) has been partially investigated; however, the clinical relevance of collective or individual NOX family member expression for HCC survival remains unclear. Here, we obtained NOX mRNA expression data for 377 HCC samples and 21 normal liver controls from the TCGA data portal and performed Kaplan-Meier survival, gene ontology functional enrichment, and gene set enrichment analyses. Although most NOX genes exhibited little change, some were significantly induced in HCC compared to that in normal controls. In addition, HCC survival analyses indicated better overall survival in patients with high NOX4 and DUOX1 expression, whereas patients with high NOX1/2/5 expression showed poor prognoses. Gene-neighbour and gene set enrichment analyses revealed that NOX1/2/5 were strongly correlated with genes associated with cancer cell survival and metastasis, whereas increased NOX4 and DUOX1 expression was associated with genes that inhibit tumour progression. On the basis of these data, NOX family gene expression analysis could be a predictor of survival and identify putative therapeutic targets in HCC.

引用

页数：10

共 34 条

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Alfarouk Khalid O, 2014, Oncoscience, V1, P777

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